The Evaluation of The Effects 2 protocols in pregnancy

GnRh-agonist microdose flare up protocol versus GnRh-antagonist/letrozole protocol in poor responders undergoing intracytoplasmic sperm ingection

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014050516858N3

Enrollment

137

Registered

2015-02-06

Start date

2012-01-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility. Female Infertility

Interventions

Intervention 1: control: The GnRh-antagonist / Letrozole group, Letrozole tablets after the expiration of a period ocp the third day of the cycle with a dose of 5/2 mg / d for 5 days. Yabd.hmzman dail

Treatment - Drugs

control: The GnRh-antagonist / Letrozole group, Letrozole tablets after the expiration of a period ocp the third day of the cycle with a dose of 5/2 mg / d for 5 days. Yabd.hmzman daily starting on t

Interventional: The GnRh-agonist, microdose Flare up with a dose of 40 mg subcutaneously every day will begin and will be continue until the day of hCG administration and 2 days post-dose ampoules

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: female patient age 18–35 years; presence of a regular ; proven ovulatory menstruation cycle with a length of 26–35 days, more that 5 million sperm in SA(semen analysis);body mass index (BMI) of 18–30 kg/m ; ?rst ICSI attempt . Exclusion criteria:established systemic disease ;ovary and Uterus abnormalities;repeated abortions

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Increase Endometrial Thickness. Timepoint: 2 Days After HCG Injection. Method of measurement: Sonography.;Increase Implantation. Timepoint: 3 weeks. Method of measurement: Lab Test.;Increase Clinical Pregnancy. Timepoint: 3 weeks. Method of measurement: Sonography.;Decrease Treatment Cost. Timepoint: Delivery Time. Method of measurement: Counting-RIALs.;Estradiol. Timepoint: Beginning time of study. Method of measurement: Lab Test.;LH. Timepoint: first and 4th week of study. Method of measurement: Lab Test.;FSH. Timepoint: first and 4th week of study. Method of measurement: Lab Test.;Chemical pregnancy. Timepoint: End of study. Method of measurement: Lab Test.	—

Measure

Time frame

Increase Endometrial Thickness. Timepoint: 2 Days After HCG Injection. Method of measurement: Sonography.;Increase Implantation. Timepoint: 3 weeks. Method of measurement: Lab Test.;Increase Clinical Pregnancy. Timepoint: 3 weeks. Method of measurement: Sonography.;Decrease Treatment Cost. Timepoint: Delivery Time. Method of measurement: Counting-RIALs.;Estradiol. Timepoint: Beginning time of study. Method of measurement: Lab Test.;LH. Timepoint: first and 4th week of study. Method of measurement: Lab Test.;FSH. Timepoint: first and 4th week of study. Method of measurement: Lab Test.;Chemical pregnancy. Timepoint: End of study. Method of measurement: Lab Test.

—

Secondary

Measure	Time frame
Increase follicular number. Timepoint: 8 days. Method of measurement: 8days.;Embryo transfer. Timepoint: delivery time. Method of measurement: fertility rate.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Sepideh Peyvandi

Mazandaran University of Medical Sciences

drspeyvandi@mazums.ac.irasdvsdpda@yahoo.comazar nabati ;+98 15 1321 3425

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026