Comparison of analgesic effects of Morphine and Indomethacin suppositories in patients with clinical diagnosis of renal colic

Comparison of analgesic effects of Morphine and Indomethacin suppositories in patients with clinical diagnosis of renal colic referred to emergency wards of Shariati and Imam Khomeini hospitals

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014050514297N2

Enrollment

158

Registered

2014-06-01

Start date

2014-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Colic. Unspecified renal colic

Interventions

Intervention 1: In the first intervention group, 100 mg Indomethacin suppository (the standard treatment for renal colic) is administered. Intervention 2: In the other group 10 mg morphine suppository

Treatment - Drugs

In the first intervention group, 100 mg Indomethacin suppository (the standard treatment for renal colic) is administered.

In the other group 10 mg morphine suppository is administered

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients between 18-85 years old with clinical diagnosis of renal colic referred to emergency ward; Consent to participate in the trial Exclusion criteria: Patient's refusal for entering the study; Pregnancy; Substance abuse; Taking analgesics 4 hours before referral; Past history of drug reaction to morphine or NSAIDs; Refuse to take rectal analgesic drug; Diarreha; Past history of chronic liver or kidney disease, COPD, Hypercapnea, Mild or severasthma, Sleep apnea syndorme, History of ileus, paralytic, Hypotension, IBD, Chronic Pancreatitis, Chronic bile duct dysfunction, Confusion, Severe anemia,Hipnotic drugs and phenothiazine, Adrenocortical dysfunction, Untreated hypothyroidism, Hypovolemia; Breast feeding; Chronic consumption of NSAIDs; Peritonitis

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The analgesic effect of drugs. Timepoint: Immediately before, 20, 40, 60 and 90 minutes after drugs administration. Method of measurement: Pain scores (VAS).	—

Secondary

Measure	Time frame
Vital sign changes. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Clinical examination.;Nausea and vomiting. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Questionnaire.;Drowsiness. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Questionnaire.;Dry mouth. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Questionnaire.;Allergy. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Clinical examination and Questionnaire.	—

Measure

Time frame

Vital sign changes. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Clinical examination.;Nausea and vomiting. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Questionnaire.;Drowsiness. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Questionnaire.;Dry mouth. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Questionnaire.;Allergy. Timepoint: Immediately before, 20, 40 and 60 minutes after administration of drugs. Method of measurement: Clinical examination and Questionnaire.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactForough Zamanian

Imam Khomeini Hospital

dr.foroughzamanian@gmail.com+98 21 6690 4848

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026