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Comparison the effects of general anesthesia with isoflurane-nitrous oxide versus propofol-alfentanil on desirable condition of extubation of patients with arch bar in mandibular fracture surgery

Comparison the effects of general anesthesia with isoflurane-nitrous oxide versus propofol-alfentanil on the desirable condition of extubation of patients with arch bar in mandibular fracture surgery

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT201405037695N4
Enrollment
60
Registered
2014-06-04
Start date
2012-01-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mandibular fracture. Fracture of mandible

Interventions

Intervention 1: Patients in one group received propofol (100 µg/kg/min) with alfentanil (1 µg/kg/min). Intervention 2: Patients in another group received isoflurane 1.2% (1 MAC) with N2O-O2 (50%-50%).
Treatment - Drugs
Patients in one group received propofol (100 µg/kg/min) with alfentanil (1 µg/kg/min).
Patients in another group received isoflurane 1.2% (1 MAC) with N2O-O2 (50%-50%). We did not have any control group in this study.

Sponsors

Vice-Chancellor for Research Qazvin University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: mandibular fracture surgery with arch bar; age 15-50 years old; ASA class I; patients' consent Exclusion criteria: consumption of narcotic; sedative or antihypertensive drugs; presence of hypertension or impairment of consciousness; sensitivity to isoflurane, nitrous oxide, propofol and alfentanil

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Desirable condition for endotrcheal extuation. Timepoint: After endotrcheal etubation in operating room. Method of measurement: By the presence of bucking, patients' cooperation for eye opening, head elevation , legs elevation and hand grasping for five seconds.

Secondary

MeasureTime frame
Blood pressure and heart rate. Timepoint: Every five minutes from five minutes before induction of anesthesia until fifteen minutes after extubation. Method of measurement: By noninvasive blood pressure and cardiovascular monitoring.;Nausea, vomiting. Timepoint: After endotracheal extubation and in recovery room. Method of measurement: Visual.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyedeh Masoumeh Hosseini Valami

Qazvin University of Medical Sciences

smhosseiniv@qums.ac.ir+98 281336001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026