The effect of vitamin D3 supplementation on glycemic indices lipid profile and liver enzymes in cirrhotic patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140502017522N2

Enrollment

Registered

2018-11-14

Start date

2019-04-21

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cirrhosis. Fibrosis and cirrhosis of liver

Interventions

Intervention 1: Intervention group: 50000 IU Vitamin D weekly for 12 weeks. Intervention 2: Control group: one placebo weekly for 12 weeks.

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: cirrhotic patients

Exclusion criteria

Exclusion criteria: Taking vitamin D since Last 3 months Pregnant women lactating Women Patient with a history of Gastroplastic or jejunostomic vitamin D level higher than 50 ng/ml

Design outcomes

Primary

Measure	Time frame
Body mass index (BMI). Timepoint: Two times: 1) before supplementation 2)After 12 weeks. Method of measurement: BMI compares weight to height, and is calculated by dividing weight (in kilograms) by height (in metres squared).;25 hydroxy vitamin D3. Timepoint: Two times: 1) before supplementation 2)After 12 weeks. Method of measurement: Units are ng / ml using 25OHD ALIZA.;Fasting blood sugar (FBS). Timepoint: Two times: 1) before supplementation 2)After 12 weeks. Method of measurement: Units are mg / dl using autoanalyzer.;HbA1c. Timepoint: Twoo times: 1) before supplementation 2)After 12 weeks. Method of measurement: Units are % using HbA1c kits.;Insulin. Timepoint: Two times: 1) before supplementation 2)After 12 weeks. Method of measurement: Units are µIU / ml using insulin kits.;Insulin Resistance. Timepoint: Two times: 1) before supplementation 2)After 12 weeks. Method of measurement: Using the index, HOMA-ir.;Cholesterol. Timepoint: Two times:1)Befor of supplementation 2)after 12 weeks. Method of measurement: In mg/dl and by autoanalyzer.;Triglycerides. Timepoint: Two times:1)Befor of supplementation 2)after 12 weeks. Method of measurement: In mg/dl and by autoanalyzer.;High Density Lipoprotein. Timepoint: Two times:1)Befor of supplementation 2)after 12 weeks. Method of measurement: In mg/dl and by autoanalyzer.;Low Density Lipoprotein. Timepoint: Two times:1)Befor of supplementation 2)after 12 weeks. Method of measurement: In mg/dl and by auto analyzer.;Aspartat Amino Teransferase (AST). Timepoint: Two times:1)Befor of supplementation 2)after 12 weeks. Method of measurement: In unit per liter and by autoanalyzer.;ALanin Amino Teransferase (AST). Timepoint: Two times:1)Befor of supplementation 2)after 12 weeks. Method of measurement: in Unit per liter and by Autoanalyser.	—

Measure

Time frame

Body mass index (BMI). Timepoint: Two times: 1) before supplementation 2)After 12 weeks. Method of measurement: BMI compares weight to height, and is calculated by dividing weight (in kilograms) by height (in metres squared).;25 hydroxy vitamin D3. Timepoint: Two times: 1) before supplementation 2)After 12 weeks. Method of measurement: Units are ng / ml using 25OHD ALIZA.;Fasting blood sugar (FBS). Timepoint: Two times: 1) before supplementation 2)After 12 weeks. Method of measurement: Units are mg / dl using autoanalyzer.;HbA1c. Timepoint: Twoo times: 1) before supplementation 2)After 12 weeks. Method of measurement: Units are % using HbA1c kits.;Insulin. Timepoint: Two times: 1) before supplementation 2)After 12 weeks. Method of measurement: Units are µIU / ml using insulin kits.;Insulin Resistance. Timepoint: Two times: 1) before supplementation 2)After 12 weeks. Method of measurement: Using the index, HOMA-ir.;Cholesterol. Timepoint: Two times:1)Befor of supplementation 2)after 12 weeks. Method of measurement: In mg/dl and by autoanalyzer.;Triglycerides. Timepoint: Two times:1)Befor of supplementation 2)after 12 weeks. Method of measurement: In mg/dl and by autoanalyzer.;High Density Lipoprotein. Timepoint: Two times:1)Befor of supplementation 2)after 12 weeks. Method of measurement: In mg/dl and by autoanalyzer.;Low Density Lipoprotein. Timepoint: Two times:1)Befor of supplementation 2)after 12 weeks. Method of measurement: In mg/dl and by auto analyzer.;Aspartat Amino Teransferase (AST). Timepoint: Two times:1)Befor of supplementation 2)after 12 weeks. Method of measurement: In unit per liter and by autoanalyzer.;ALanin Amino Teransferase (AST). Timepoint: Two times:1)Befor of supplementation 2)after 12 weeks. Method of measurement: in Unit per liter and by Autoanalyser.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyedeh Roghayeh Derogar Kasmaei

Bagheiat-allah University of Medical Sciences

sr_derogar@yahoo.com+98 21 8248 3511

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 5, 2026