The effect of 8 weeks versus 12 weeks steroid therapy on serum 25-hydroxy vitamin D level in children with nephrotic syndrome during remission phase

The effect of 8 weeks versus 12 weeks steroid therapy on serum 25-hydroxy vitamin D level in children with nephrotic syndrome during remission phase: a randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201404269014N33

Enrollment

Registered

2014-05-03

Start date

2013-07-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nephrotic syndrome. Nephrotic syndrome

Interventions

Intervention 1: oral prednisolone 60 mg/square meter daily for 6 weeks and then oral prednisolone 40 mg/square meter every other day for 6 weeks (totally 12 weeks). Intervention 2: oral prednisolone 6

Treatment - Drugs

oral prednisolone 60 mg/square meter daily for 6 weeks and then oral prednisolone 40 mg/square meter every other day for 6 weeks (totally 12 weeks).

oral prednisolone 60 mg/square meter daily for 4 weeks and then oral prednisolone 40 mg/square meter every other day for 4 weeks (totally 8 weeks).

Eligibility

Sex/Gender

All

Age

1 Years to 18 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: (a) age of 1-18 years; (b) affected with nephrotic syndrome; (c) being in remission phase. Exclusion criteria: (a) children with malnutrition; (b) receiving vitamin D supplement during the last three months; (c) having liver, pancreatic, or gastrointestinal diseases; (d) using phenytoin, phenobarbital, isoniazid, or rifampin.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The serum 25-hydroxy vitamin D level. Timepoint: at the end of treatment. Method of measurement: through taking blood sample.	—

Secondary

Measure	Time frame
Measuring the relapse of nephrotic syndrome. Timepoint: at the end of treatment. Method of measurement: through taking urine sample and measuring proteinuria equal to or greater than 2 plus.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Aminosadat Sharif

Beasat Hospital

amin.sharif63@yahoo.com+98 81 1264 0040

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026