Effect of Folic Acid on Bone Metabolism: A Randomized Double Blind Clinical Trial in Postmenopausal osteoporosis Women

Effect of Folic Acid on Bone Metabolism in Post-Menopausal Osteoporotic Women: A Randomized Double Blind Clinical Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014042217385N1

Enrollment

Registered

2014-05-20

Start date

2011-07-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoporosis. Senile Osteoporosis

Interventions

Intervention 1: Folic Acid Tablet 1 mg/day. Intervention 2: Placebo 1 Tablet Per Day.

Prevention

Placebo

Folic Acid Tablet 1 mg/day

Placebo 1 Tablet Per Day

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Age= 50-60yrs; Postmenopausal Women; Osteoporosis. Exclusion Criteria: History of Cancer; Acute Infection; Endocrinologic Diseases; Taking Medicines Affecting Bone Metabolism Such As Corticosteroids;Gonadotropine Releasing Hormone (GnRH) Analogues; Anticonvulsant Drugs; Heparin; Aluminum Containing Antacids; Thyroid Hormones.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pyridinoline. Timepoint: At Baseline, 3 and 6 Months Later. Method of measurement: µg/mmol cr.;Osteocalcin. Timepoint: At Baseline, 3 and 6 Months Later. Method of measurement: ng/ml.;Bone Alkaline Phosphatase. Timepoint: At Baseline, 3 and 6 Months Later. Method of measurement: U/L.;U ß Cross Laps. Timepoint: At Baseline, 3 and 6 Months Later. Method of measurement: µg/mmol cr.;Bone density. Timepoint: Before. Method of measurement: Gm/cm2.	—

Measure

Time frame

Pyridinoline. Timepoint: At Baseline, 3 and 6 Months Later. Method of measurement: µg/mmol cr.;Osteocalcin. Timepoint: At Baseline, 3 and 6 Months Later. Method of measurement: ng/ml.;Bone Alkaline Phosphatase. Timepoint: At Baseline, 3 and 6 Months Later. Method of measurement: U/L.;U ß Cross Laps. Timepoint: At Baseline, 3 and 6 Months Later. Method of measurement: µg/mmol cr.;Bone density. Timepoint: Before. Method of measurement: Gm/cm2.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactPooneh Salari

Medical Ethics and History of Medicine Research Center of Tehran University of Medical Sciences

poonehsalari@gmail.com; salari@tums.ac.ir+98 21 6641 9661

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 19, 2026