To compare the effect of intravenous Rapifen and Lidocaine to control hemodynamic responses in laryngoscopy and intubation

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014042117373N1

Enrollment

120

Registered

2014-10-20

Start date

2014-07-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General anesthesia. Other complications of anesthesia

Interventions

Intervention 1: In group A, patients receive routine anesthesia, and distilled water 1.5 minutes before laryngoscopy and intubation .Distilled water is placebo. Intervention 2: In addition to induce r

patients in group B receive intravenous Lidocaine (1.5 milligram per kilogram) 1.5 minutes before laryngoscopy and intubation. Intervention 3: In addition to induce routine anesthesia

patients in group C receive intravenous Rapifen (10 microgram per kilogram) 1.5 minutes before laryngoscopy and intubation. Intervention 4: In addition to induce routine anesthesia

patients in group D receive intravenous Lidocaine (1.5 milligram per kilogram) plus Rapifen (10 microgram per kilogram) 1.5 minutes before laryngoscopy and intubation.

Treatment - Drugs

In group A, patients receive routine anesthesia, and distilled water 1.5 minutes before laryngoscopy and intubation .Distilled water is placebo.

In addition to induce routine anesthesia

patients in group B receive intravenous Lidocaine (1.5 milligram per kilogram) 1.5 minutes before laryngoscopy and intubation

patients in group C receive intravenous Rapifen (10 microgram per kilogram) 1.5 minutes before laryngoscopy and intubation

patients in group D receive intravenous Lidocaine (1.5 milligram per kilogram) plus Rapifen (10 microgram per kilogram) 1.5 minutes before laryngoscopy and intubation

Eligibility

Sex/Gender

All

Age

15 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclsion criteria:patients with 15 years old to 60 years old . Exclusion criteria: addiction ? patients with heart disease ? respiratory diease ? hypertension( >140/90) ? chronic dease with giving analgesic drugs ? pregnancy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Blood pressure. Timepoint: Before sedation , before induction , 20 s after laryngoscopy , 5 minutes after laryngoscopy. Method of measurement: Blood pressure measurement divice.;Heart rate. Timepoint: Berore sedation , before induction , 20 s after laryngoscopy , 5 minutes after laryngoscopy. Method of measurement: Monitoring of heart rate divice.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKambiz Boroojli

Qazvin University of Medical Siences

kboroojli@qums.ac.ir+98 28033790620

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026