The effects of intravenous Paracetamol and Indomethacin suppository for treating pain after septorhinoplasty surgery

Comparison of the effects of intravenous Paracetamol and Indomethacin suppository for pain relief after septorhinoplasty

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014041815322N2

Enrollment

Registered

2015-04-20

Start date

2014-04-28

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain after septorhinoplasty surgery. Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

Interventions

Intervention 1: Group 1 receives a single dose of 1 gr Paracetamol IV in 100 ml normal saline, 20 minutes before the end of surgery. Intervention 2: Group 2 receives a single dose of rectal Indomethac

Treatment - Drugs

Group 1 receives a single dose of 1 gr Paracetamol IV in 100 ml normal saline, 20 minutes before the end of surgery.

Group 2 receives a single dose of rectal Indomethacin 100 mg, 20 minutes before the end of surgery.

Group 3 receives Normal saline 100 ml infusion, 20 minutes before the end of surgery.

Eligibility

Sex/Gender

All

Age

75 Years to 43 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ASA class 1-2, 18-50 years- old patients Exclusion criteria: drug or alcohol abuse; allergy to study drugs or their constituents; history of renal or hepatic failure or disease; asthma; peptic ulcer; a history of seizures; history of chronic pain.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Postoperative pain scores. Timepoint: 15 and 30 min and at 1, 2, 3, 4, 5, 6 ,7, and 8 hours after surgery. Method of measurement: A o to 10 visual analogue scale (VAS) score.	—

Secondary

Measure	Time frame
Supplementary analgesia. Timepoint: During 8 hours study period. Method of measurement: if pain scores are 4 or greater or on patient's demands.;Sedation scores. Timepoint: 15 and 30 min , and 1, 2, 3, 4,5,6,7, and 8 hours after surgery. Method of measurement: Ramsay Sedation Score.;Adverse effects. Timepoint: Continuously during 8 hours study period. Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMiss Yalda Parviz

Azad University of Pharmaceutical Sciences, College of Pharmacy

yali_par@yahoo.com+98 21226400515

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026