Diagnosis of acute kidney injury in patients undergoing off-pump coronary artery bypass

Determination of the rate of acute kidney injury incidence, following fluid resuscitation with ?isotonic saline compared to Ringer lactate in patients undergoing off-pump coronary bypass, ?hospitalized in the intensive care unit (ICU)

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014041813159N3

Enrollment

966

Registered

2014-06-15

Start date

2014-05-25

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney injury. Chronic kidney disease, unspecified

Interventions

Intervention 1: Control group: Isotonic saline 0.9% containing 154 mEq chlorine ion, 30 ml/kg at 24 hours after surgery. Intervention 2: Intervention group: Ringer lactate containing 109 mEq chlorine

Diagnosis

Control group: Isotonic saline 0.9% containing 154 mEq chlorine ion, 30 ml/kg at 24 hours after surgery

Intervention group: Ringer lactate containing 109 mEq chlorine ion, 30 CC/kg at 24 hours after surgery.

Eligibility

Sex/Gender

All

Age

20 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ?patients after undergoing elective on-?pump coronary ?bypass. Exclusion criteria: Emergency surgical operation; Previous history of ?cardiac surgery; American Society of Anesthesiologists Class (ASA) more than 4; Previous history of ?kidney diseases; Diabetic nephropathy; Preoperative serum creatinine level more than 1.3; ?Preoperative glomerular filtration rate (GFR) less than 75%, 8) preoperative ejection fraction ??(EF) less than 30%; Drainage more than the volume during the surgery; Use of a balloon pump ?during or after the surgery; Prolonged recurrent ventricular fibrillation (VF) during the surgery; ?High dose inotrope (inotrope 2) during the surgery; Lack of patient’s consent to participate in ?the study.? Patients are also excluded during the study period if hyperchloremia (CL more than 110) occurs ?in the ICU, Various complications might occur (hemorrhage, drainage, cardiac arrest, ?prolonged hemodynamic instability, and neurological complications of CVA), which result in the ?exclusion of patients from the study.?

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Arterial blood gases. Timepoint: Before and at the first 24 hours after intervention, every 4 hours. Method of measurement: Blood test.;Blood urea nitrogen?. Timepoint: Before and after intervention, daily. Method of measurement: Venous blood samples from the arm.;Blood creatinine level. Timepoint: After intervention, daily. Method of measurement: Blood test, jaffe method.;Sodium. Timepoint: Before and at the first 24 hours after intervention, every 4 hours. Method of measurement: Blood test.;Lactate. Timepoint: Before and after intervention, daily. Method of measurement: Blood test.	—

Measure

Time frame

Arterial blood gases. Timepoint: Before and at the first 24 hours after intervention, every 4 hours. Method of measurement: Blood test.;Blood urea nitrogen?. Timepoint: Before and after intervention, daily. Method of measurement: Venous blood samples from the arm.;Blood creatinine level. Timepoint: After intervention, daily. Method of measurement: Blood test, jaffe method.;Sodium. Timepoint: Before and at the first 24 hours after intervention, every 4 hours. Method of measurement: Blood test.;Lactate. Timepoint: Before and after intervention, daily. Method of measurement: Blood test.

—

Secondary

Measure	Time frame
Chlorine. Timepoint: Daily after intervention. Method of measurement: Blood test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElham Behnamfar

Mashhad University of Medical sciences

behnamfare861@mums.ac.ir0098915?7339616?

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026