Effect of melatonin on fertility in women with loss of ovarian reserve

Evaluation of the effect of melatonin on the success of invitro fertilization in women with decreased ovarian reserve.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014041417264N1

Enrollment

Registered

2014-06-08

Start date

2014-06-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premature ovarian failure (POF). Decreased estrogen - Premature menopose NOS - Resistant ovary syndrome .

Interventions

Intervention 1: ]n the case group ,the paitent recieve melatonin by does of 3 mg/day from 5'th day of sycle till pick-up day . Intervention 2: ]n the control group ,the paitent recieve pelacebo caps

Treatment - Drugs

]n the case group ,the paitent recieve melatonin by does of 3 mg/day from 5'th day of sycle till pick-up day .

]n the control group ,the paitent recieve pelacebo capsule one every night from 5'th day of sycle till pick-up day .

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: inclusion criteria: ART for the first time, normal male factor, normal uterine cavity and presence of two of the three following criteria first; summation of bilateral AFC = 6, second; AMH=1 and third; basal FSH on the 3rd day of menstrual cycle=10. exclusion criteria: couple declined to participate, the protocol was not exactly followed or the ovaries showed poor responses to gonadotropins

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Number of ovum have received in each IVF cycle. Timepoint: On day of ovum pick up and emberyo insercion (IVF). Method of measurement: - Measuring number of ovumes on the day of pick up in lab by pathologist under microscope (GV , MI , MII ) and quality of emberyo also by the same pathologist due to kind of cell division ( Grade I , II , III , IV).;Quality of ovum have received in each IVF cycle. Timepoint: On day of ovum pick up and emberyo insercion (IVF). Method of measurement: Measuring quality of ovumes on the day of pick up in lab by pathologist under microscope (GV , MI , MII ) and quality of emberyo also by the same pathologist due to kind of cell division ( Grade I , II , III , IV).;Number of emberyo have received in each IVF cycle. Timepoint: On day of ovum pick up and emberyo insercion (IVF). Method of measurement: Measuring number of emberyo on the day of pick up in lab by pathologist under microscope (GV , MI , MII ) and quality of emberyo also by the same pathologist due to kind of cell division ( Grade I , II , III , IV).;Quality of emberyo have received in each IVF cycle. Timepoint: On day of ovum pick up and emberyo insercion (IVF). Method of measurement: Measuring quality of emberyo on the day of pick up in lab by pathologist under microscope (GV , MI , MII ) and quality of emberyo also by the same pathologist due to kind of cell division ( Grade I , II , III , IV).	—

Measure

Time frame

Number of ovum have received in each IVF cycle. Timepoint: On day of ovum pick up and emberyo insercion (IVF). Method of measurement: - Measuring number of ovumes on the day of pick up in lab by pathologist under microscope (GV , MI , MII ) and quality of emberyo also by the same pathologist due to kind of cell division ( Grade I , II , III , IV).;Quality of ovum have received in each IVF cycle. Timepoint: On day of ovum pick up and emberyo insercion (IVF). Method of measurement: Measuring quality of ovumes on the day of pick up in lab by pathologist under microscope (GV , MI , MII ) and quality of emberyo also by the same pathologist due to kind of cell division ( Grade I , II , III , IV).;Number of emberyo have received in each IVF cycle. Timepoint: On day of ovum pick up and emberyo insercion (IVF). Method of measurement: Measuring number of emberyo on the day of pick up in lab by pathologist under microscope (GV , MI , MII ) and quality of emberyo also by the same pathologist due to kind of cell division ( Grade I , II , III , IV).;Quality of emberyo have received in each IVF cycle. Timepoint: On day of ovum pick up and emberyo insercion (IVF). Method of measurement: Measuring quality of emberyo on the day of pick up in lab by pathologist under microscope (GV , MI , MII ) and quality of emberyo also by the same pathologist due to kind of cell division ( Grade I , II , III , IV).

—

Secondary

Measure	Time frame
- Clinical pregnancy. Timepoint: - 4 – 6 weeks after emberyo transfering. Method of measurement: - Serum BHCG and TVS.;Misscariage. Timepoint: 4-6 week after trasfer day. Method of measurement: serum BHCG and TVS.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Sara Sadeghi

Shiraz university of medical science

sarasadeghi80@yahoo.com+98 71 1227 9715

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026