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Investigation of the effect of diphencypron on treatment of acute urban leishmaniasis with intralesional injection of glucantime

Investigation of the therapeutic effect of diphencyprone induced local hypersensitivity on treatment of acute urban leishmaniasis with intralesional injection of glucantime

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20140414017271N6
Enrollment
44
Registered
2019-02-17
Start date
2017-11-01
Completion date
Unknown
Last updated
2019-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cutaneous leishmaniasis. Cutaneous leishmaniasis

Interventions

Intervention 1: Intervention group: At the same time as intralesional injection of glucantime, after sensitization with 2% diphencyprone (produced by the American corporation Sigma)solution on the upp

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Positive smear or biopsy of the lesion in terms of Leishman body Lesion in limbs dry leishmaniasis The patient has an indication of topical treatment based on the judgment of the therapist and the national protocol for leishmania A maximum of 6 months has elapsed since the onset of the lesion The patient has an informed consent to participate in the study.

Exclusion criteria

Exclusion criteria: Sensitivity to intralesional injection of glucantime The presence of secondary infection in the lesion based on the researcher's judgment Pregnancy or breastfeeding Wet leishmaniasis, Lupoid, Sporotricoid

Design outcomes

Primary

MeasureTime frame
The rate of recovery in the two groups. Timepoint: Every week after the injection up to 12 weeks. Method of measurement: Size of the lesions will be recorded using a ruler and stiffness and induration will also be recorded based on examination in each session.;The amount of time needed for the lesions to heal. Timepoint: Every week until lesion recovery. Method of measurement: Based on the number of weeks passed until recovery.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFaeze Taghavi

Mashhad University of Medical Sciences

taghavif941@mums.ac.ir+98 51 3802 5732

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026