Effects of Green Tea Consumption on NAFLD

Effects of Green Tea Consumption on Blood Iron indices, Oxidative Stress and Hemojuvelin Gene expression in NAFLD Patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201404132365N8

Enrollment

Registered

2014-05-17

Start date

2014-05-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nonalcoholic fatty liver disease (NAFLD). Fatty (change of) live, not elsewhere classified

Interventions

Intervention 1: Intervention group: green tea catechins (ECGC) 450 mg/d for three months. Intervention 2: Control group: placebo for three months.

Treatment - Drugs

Intervention group: green tea catechins (ECGC) 450 mg/d for three months

Control group: placebo for three months

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Known case of NAFLD, diagnosed by ultrasound of the liver, liver biopsy or liver Fibroscan; age 18 years or older; willingness to participate in research. Lack of inclusion criteria: iron deficiency anemia (hemoglobin less than 12 for women and 13 for men); allergy to green tea; alcohol consumption more than 20 g daily; viral hepatitis B and C; autoimmune hepatitis; celiac; wilson; alpha- antitrypsin deficiency. Exclusion criteria: symptoms of allergy or adverse effects of green tea consumption; taking less than 80% of the delivered dose of green tea; pregnancy or lactation; unwillingness to continue the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Hemojuvelin gene expression. Timepoint: Before and after intervention. Method of measurement: Polymerase chain reaction (PCR).;Blood iron indices. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Insulin resistance. Timepoint: Before and after intervention. Method of measurement: HOMA Index.;Total antioxidant capacity. Timepoint: Before and after intervention. Method of measurement: Laboratory.	—

Measure

Time frame

Hemojuvelin gene expression. Timepoint: Before and after intervention. Method of measurement: Polymerase chain reaction (PCR).;Blood iron indices. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Insulin resistance. Timepoint: Before and after intervention. Method of measurement: HOMA Index.;Total antioxidant capacity. Timepoint: Before and after intervention. Method of measurement: Laboratory.

—

Secondary

Measure	Time frame
Fasting blood sugar. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Liver enzymes. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Serum insulin. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Body mass index. Timepoint: Before and after intervention. Method of measurement: Body mass index.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Reza Vafa

Iran University of Medical Sciences

mrvafa@tums.ac.ir; vafa.m@iums.ac.ir+98 21 8670 4734

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026