The effect of melatonin, clonidine, and gabapentin on reducing the preoperative anxiety and postoperative pain in patients undergoing laparoscopic cholecystectomy

A comparative study of the effect of melatonin, clonidine or gabapentin on reducing the preoperative anxiety and postoperative pain in patients undergoing laparoscopic cholecystectomy in Shariati Hospital in 1393

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014041217231N1

Enrollment

Registered

2014-07-01

Start date

2014-06-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Epigastric Pain. Condition 2: Anxiety. Pain localized to upper abdomen Anxiety NOS

Interventions

Intervention 1: Placebo, 120min before surgery. Intervention 2: melatonin 6mg, 120min before surgery. Intervention 3: clonidine 0.2mg, 120min before surgery. Intervention 4: Gabapentin 600mg, 120min b

Placebo

Treatment - Drugs

Placebo, 120min before surgery

melatonin 6mg, 120min before surgery

clonidine 0.2mg, 120min before surgery

Gabapentin 600mg, 120min before surgery

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Patients scheduled for elective laparoscopy cholecystectomy; Signing the informed written consent; Exclusion Criteria:History of congenital heart diseases; History of heart valve diseases; History of liver or kidney diseases; History of psychological disorders; Opioid addiction; Uncontrolled hypertension; Patients with verbal or communication difficulties

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Anxiety. Timepoint: The night before the surgery and when entering the operating room. Method of measurement: STAI questionnaire.;Pain. Timepoint: 2 h before and 1 h, 2 h, 6 h, 12 h, and 24 h after the surgery. Method of measurement: VAS, PCA.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactVahideh Sadat Hosseini

Shariati Hospital

dr.vahideh.hosseini@gmail.com+98 21 8490 1001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026