brucellosis. Brucellosis due to Brucella melitensis
Conditions
Interventions
Intervention 1: Gentamicin 4-5 mg /kg (IM)for one week and doxycycline 100 mg/bid (oral) for 45 days, plus rifampin 600-900 mg /daily( oral) for 45 days orally. Intervention 2: Gentamicin 4-5 mg /kg f
Treatment - Drugs
Gentamicin 4-5 mg /kg (IM)for one week and doxycycline 100 mg/bid (oral) for 45 days, plus rifampin 600-900 mg /daily( oral) for 45 days orally.
Gentamicin 4-5 mg /kg for one week as an injection and doxycycline 100 mg/bid for 45 days
Sponsors
Babol University of Medical Sciences
Eligibility
Sex/Gender
All
Age
8 Years to 130 Years
Inclusion criteria
Inclusion criteria: After providing adequate information eligible patients volenteer will be enrolled in the study. Inclusion criteria:Patients who have received no treatment,Clinical signs and positive Blood culture,positive serological tests such as Wright and 2ME and Coombs Wright. Exclusion criteria : pregnant women and children less than 8 years, patients with endocarditis, meningitis or spondylitis , Negative PCR tests are also excluded
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA of Brucella bacteria. Timepoint: Three sections: in first day of the study, end of the sixth week, end of the sixth month. Method of measurement: PCR.;Brucella bacteria. Timepoint: Three sections: in first day of the study, end of the sixth week, end of the sixth month. Method of measurement: Blood culture.;Antibody of serum. Timepoint: Before treatment, 6 weeks after begining of treatment, 6months after end of treatment. Method of measurement: Wright test, 2ME, Coombs. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mohammad Reza Hassanjani Roshan
Babol University of Medical Sciences
Outcome results
None listed