Skip to content

Topical Tacrolimus in acute corneal graft rejection

Comparison of efficacy of adjunctive topical Tacrolimus 0.05% to conventional steroid therapy in treatment of acute corneal graft rejection in Farabi Eye Hospital 1392-94

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014040617088N1
Enrollment
60
Registered
2015-01-22
Start date
2014-05-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute endothelial corneal graft rejection. Postprocedural disorder of eye and adnexa, unspecified

Interventions

Intervention 1: Intervention for group 1: topical prednisolone acetate 1% every 2 hours tapering every week to half and oral prednisolone 1 mg/kg tapering to half every week. Intervention 2: intervent
Treatment - Drugs
Intervention for group 1: topical prednisolone acetate 1% every 2 hours tapering every week to half and oral prednisolone 1 mg/kg tapering to half every week
intervention for group 2: topical tacrolimus 0.05% drop every 6 hours in addition to medication for group 1 until resolution of rejection

Sponsors

Tehran University of Medical Sciences, Farabi Eye Hospital research center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with acute corneal endothelial rejection Exclusion criteria:history of herpetic keratitis; immunosuppressive therapy; one eye patient; mild rejection episode

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Resolution of rejection. Timepoint: Time to resolution of rejection. Method of measurement: clinical examination.

Secondary

MeasureTime frame
Recurrence of rejection. Timepoint: time of recurrence. Method of measurement: clinical examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGolshan Latifi

Tehran University of Medical Sciences, Farabi Eye Hospital

golshan24@yahoo.com+98 21 5540 0003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026