The Effect of Pharmapain and Dexamethasone on Reducing Pain during Root Canal Therapy of Mandibular Teeth

Clinical Trial of Comparison of the Effect of Premedication with Pharmapain, Dexamethasone and Placebo on Pain Severity after Administration of Anesthesia in Inferior Molar Teeth with Irreversible Pulpitis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014040417118N1

Enrollment

210

Registered

2015-08-13

Start date

2014-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversible Pulpitis. Diseases of pulp and periapical tissues

Interventions

Intervention 1: Control2 intervention group one Capsule Dexamethasone 0.5 mg(Aburaihan Pharmaceutical Co, Iran) 30 min before injection Intervention category treatment. Intervention 2: Control3 contro

Treatment - Drugs

Placebo

Control2 intervention group one Capsule Dexamethasone 0.5 mg(Aburaihan Pharmaceutical Co, Iran) 30 min before injection Intervention category treatment

Control3 control group one Capsule (placebo: Lactose) 30 min before injection

intervention groups one Capsule pharmapain 400 mg( Pharma chemie Pharmaceutical Co , Iran) 30 min before injection

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Age over than 18 years old; first or second Molar teeth with irreversible pulpitis; Normal peri-radicular status according to radiography. Exclusion Criteria: Hypersensitivity to lidocaine; Impossible to restore the teeth ; Presence of a crown before the procedure ; Internal or external resorption ; Teeth with open apices ;Breast-feeding ; Pregnancy; Use of analgesics 12 hours before treatment; No sign of soft tissue anesthesia.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Inferior alveolar nerve block. Timepoint: 45 minute after intervention (15 minute after injection). Method of measurement: visual analog scale.	—

Secondary

Measure	Time frame
Analgesia during access cavity preparation and entrance into the root canal. Timepoint: during access cavity preparation and entrance into the pulp chamber. Method of measurement: visual analog scale.	—

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026