Effect of green tea consumption in the treatment of patients with beta-thalassemia major

Effect of green tea consumption on iron stores, metabolic and oxidative status in beta-thalassemia major patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201403303664N10

Enrollment

Registered

2014-11-29

Start date

2014-11-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Beta thalassaemia. Beta thalassaemia

Interventions

Intervention 1: Intervention group will receive daily 3 cups of green tea immediately after the meal for 8 weeks (each cup of green tea is produced by putting green tea bag contains 2.5 grams in 150 c

Treatment - Drugs

Intervention group will receive daily 3 cups of green tea immediately after the meal for 8 weeks (each cup of green tea is produced by putting green tea bag contains 2.5 grams in 150 cc of boiled wate

Control group 3 cups lukewarm boiled water daily over the same period (per cup after meal consumption).

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Beta-thalassemia disease; usage of chelator drug deferoxamine; not suffering from viral hepatitis B and C; having over 18 years of age and not use of any antioxidant supplements 3 months before intervention. Exclusion criteria: Absence of any of the above conditions will result in withdrawal from the study subjects

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Iron stores levels ( Iron serum, Ferritin serum, Transferrin Saturation and TIBC). Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: Spectrophotometry for Iron serum and TIBC, ELISA assay for ferritin and Iron serum/TIBC* 100 for Transferrin Saturation.;Liver enzymes (AST, ALT). Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: Spectrophotometry.;Lipid profiles (TC, TG, LDL-C, HDL-C). Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: Enzymatic methods for TC,TG and HDL-C For LDL-C : Freidwald’s formula: LDL-C = TC- HDL-C - (TG/5).;Serum Total Antioxidant Capacity. Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: Spectrophotometry.;Serum Malondialdehyde (MDA). Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: Spectrophotometry.	—

Measure

Time frame

Iron stores levels ( Iron serum, Ferritin serum, Transferrin Saturation and TIBC). Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: Spectrophotometry for Iron serum and TIBC, ELISA assay for ferritin and Iron serum/TIBC* 100 for Transferrin Saturation.;Liver enzymes (AST, ALT). Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: Spectrophotometry.;Lipid profiles (TC, TG, LDL-C, HDL-C). Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: Enzymatic methods for TC,TG and HDL-C For LDL-C : Freidwald’s formula: LDL-C = TC- HDL-C - (TG/5).;Serum Total Antioxidant Capacity. Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: Spectrophotometry.;Serum Malondialdehyde (MDA). Timepoint: Baseline and after 8 weeks of intervention. Method of measurement: Spectrophotometry.

—

Secondary

Measure	Time frame
Macronutrients intake. Timepoint: Before and after 8 weeks intervention. Method of measurement: 24-h Recall Questionnaire.;Anthropometric index(weight and Body Mass Index). Timepoint: Before and after 8 weeks intervention. Method of measurement: Analogue scale for weight and weight (Kg) /Square Height for Body Mass Index.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsan Soeizi

Tabriz University of Medical Siences

Esoeizi@gmail.com+98 41 3656 0683

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026