Sexual dysfunction. Lack or loss of sexual desire
Conditions
Interventions
Intervention 1: intervention group- bupropion tab.100 mg Po for 3 days, then twice daily( 200mg/day) for 8 weeks. Intervention 2: control group: Placebo tab.100 mg po for 3 days, then twice daily( 200
Treatment - Drugs
intervention group- bupropion tab.100 mg Po for 3 days, then twice daily( 200mg/day) for 8 weeks.
control group: Placebo tab.100 mg po for 3 days, then twice daily( 200mg/day) for 8 weeks.
Sponsors
Isfahan University of Medical Sciences-Behavioral Sciences Research Center
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Inclusion criteria: Male gender;Having the minimum level of education in reading and writing; passing at least 6 months from the Methadone maintenance Therapy( MMT); Having complaints from the cause or aggravate of sexual dysfunction after methadone treatment; Lack of underlying diseases as epilepsy, diabetes, organic brain disease, and psychosis;Not receiving drugs affecting sexual function, such as SSRI, sildenafil, testosterone, antipsychotics, cyclic antidepressants, MAO-I, the lithium, amphetamines, chlordiazepoxide, clonidine, methyldopa, spironolactone hydrochlorothiazide, barbiturates, anti-Parkinson's drugs , clofibrate, digoxin, indomethacin, propranolol and phentolamine; No risk of major depressive disorder and a score of less than 16 based on the BDI-II, Having a total score of 19 or more based on the Arizona Sexual Experience Scale (ASEX) or a score of 5 or more on one of the items of ASEX or a score of 4 or more in any of 3 items; No alcohol consumption, recent cessation of benzodiazepines, and not using drugs or stimulants. Exclusion criteria: Leaving the MMT program; the decision of the therapist to stop the treatment with methadone or bupropion for any reason, and seizures.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sexual function. Timepoint: preintervention, post intervention at the end of 2, 4, 6,and 8 weeks. Method of measurement: Arizona sexual experiences scale(ASEX). | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression total score. Timepoint: preintervention, post intervention at the end of 2,4,6 and 8 weeks. Method of measurement: Beck depression scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehrdad Salehi
Behavioral Sciences Research Center- Isfahan University of Medical Sciences
Outcome results
None listed