Effect of Propofol, Ketamin and their combination on post operative coughing

Effect of Propofol, Ketamin and combination of Propofol and Ketamine in prevention of coughing and laryngospasm in patients awakening from general anesthesia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201403255362N18

Enrollment

160

Registered

2014-05-31

Start date

2011-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post extubation coughing and laryngospasm. Other postprocedural respiratory disorders

Interventions

Intervention 1: control group:received propofol 0.1 ml/kg normal saline, Intravenously, when the patient’s breathing returned to regular spontaneous pattern, or when the patient opened his eyes or mad

Treatment - Drugs

control group:received propofol 0.1 ml/kg normal saline, Intravenously, when the patient’s breathing returned to regular spontaneous pattern, or when the patient opened his eyes or made purposeful mov

propofol group:received propofol 0.25 mg/kg, Intravenously, when the patient’s breathing returned to regular spontaneous pattern, or when the patient opened his eyes or made purposeful movements

Ketamine group: received ketamine 0.25 mg/kg, Intravenously, when the patient’s breathing returned to regular spontaneous pattern, or when the patient opened his eyes or made purposeful movements

combination group:propofol group:received propofol and ketamine each one, 0.25 mg/kg, Intravenously, when the patient’s breathing returned to regular spontaneous pattern, or when the patient opened hi

Eligibility

Sex/Gender

All

Age

17 Years to 75 Years

Inclusion criteria

Inclusion criteria: inclusion criteria:American Society of Anesthesiologists (ASA) class I or II; age between 7 to 75 years old; either sex exclusion criteria: history of sleep apnea syndrome; developmental disorders, airway or facial abnormalities; bronchial asthma; allergic disorders; upper respiratory infection symptom during the surgery; smoking; medication with ACE inhibitors or ;occurrence of allergic reaction ; need to change the anesthesia technique.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Coughing. Timepoint: between 1 and 3min after intervention. Method of measurement: observation.;Laryngospasm. Timepoint: between 1 and 3min after intervention. Method of measurement: observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyyed Mohammad Reza Safavi Homami

Isfahan University of Medical sciences

safavi@med.mui.ac.ir+98 31 1624 9031

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026