Effect of glucosamine consumption on blood glucose and insulin levels in type 2 diabetic patients

The effect of glucosamine supplementation on fasting blood glucose, fasting insulin, glycosylated hemoglobin and insulin resistance in type 2 diabetic patients: a randomized, double-blind and placebo-controlled trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014031811785N2

Enrollment

Registered

2014-04-05

Start date

2006-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus. Non-insulin-dependent diabetes mellitus

Interventions

Intervention 1: Placebo capsules containing calcium phosphate, once a day, for twelve weeks, edible, made in Shiraz School of Pharmacy. Intervention 2: Glucosamine hydrochloride supplement, 1500 mg, o

Placebo

Treatment - Drugs

Placebo capsules containing calcium phosphate, once a day, for twelve weeks, edible, made in Shiraz School of Pharmacy

Glucosamine hydrochloride supplement, 1500 mg, once a day, for 12 weeks, edible, Vitamin World Company of USA

Eligibility

Sex/Gender

All

Age

40 Years to 79 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Confirmed diagnosis of type 2 diabetes; fasting blood sugar <150 mg/dl; glycosylated hemoglobin <7%; management of diabetes with a stable dose of hypoglycemic drugs. Exclusion criteria: Insulin therapy; having shellfish allergy; use of any medications which alter glucose control; having history of cardiovascular diseases and thyroid disorders

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Fasting blood glucose. Timepoint: Weeks of 0, 4, 8 and 12. Method of measurement: Auto Analyzer, unit: mg/dl.;Fasting insulin. Timepoint: Weeks of 0, 8 and 12. Method of measurement: ELISA method, unit: µu/ml.;Glycosylated hemoglobin. Timepoint: Weeks of 0, 8 and 12. Method of measurement: Ion exchange chromatography, unit: percent.;HOMA index. Timepoint: Weeks of 0, 8 and 12. Method of measurement: According to formula.;QUICKI index. Timepoint: Weeks of 0, 8 and 12. Method of measurement: According to formula.	—

Measure

Time frame

Fasting blood glucose. Timepoint: Weeks of 0, 4, 8 and 12. Method of measurement: Auto Analyzer, unit: mg/dl.;Fasting insulin. Timepoint: Weeks of 0, 8 and 12. Method of measurement: ELISA method, unit: µu/ml.;Glycosylated hemoglobin. Timepoint: Weeks of 0, 8 and 12. Method of measurement: Ion exchange chromatography, unit: percent.;HOMA index. Timepoint: Weeks of 0, 8 and 12. Method of measurement: According to formula.;QUICKI index. Timepoint: Weeks of 0, 8 and 12. Method of measurement: According to formula.

—

Secondary

Measure	Time frame
Body mass index. Timepoint: Weeks of 0 and 12. Method of measurement: According to formula, unit: Kg/m2.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Zohreh Mazloom

School of Nutrition and Food Sciences, Shiraz University of Medical Sciences

zohreh.mazloom@gmail.com+98 71 1725 1001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026