Comparison the effect of Morphine ,Paracetamol and Ketorolac with Patient Control Analgesia in post operative pain in open cholecystectomy surgery

Comparison the effect of Paracetamol and Morphine and Ketorolac with IV_PCA in control of post operative pain in open cholecystectomy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014031717048N1

Enrollment

330

Registered

2014-09-17

Start date

2013-09-14

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain control. Pain localized to upper abdomen

Interventions

Intervention 1: Morphine, controlling pain after laparatomy surgery (cholecystectomy). with maximum dose 0.02 mg per kg in hour with intravenous PCA. lasting 8 hour after surgery. Intervention 2: Para

Treatment - Drugs

Morphine, controlling pain after laparatomy surgery (cholecystectomy). with maximum dose 0.02 mg per kg in hour with intravenous PCA. lasting 8 hour after surgery.

Paracetamol. controlling painafter laparotomy surgery (cholecystectomy). with maximum dose 1 mg per kg per hour with intravenous PCA. lasting 8 hours after surgery.

Ketorolac controlling pain after laparatomy surgery (cholecystectomy).with maximum dose1 mg per kg withintravenous PCA.lasting 8 hours after surgery

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria : Patient with ASA 1 and 2 ; 20 _50 years ; who werwe undergoing open cholecystectomy operation ; takes less than 2.5 hours . Exclusiom criteria : People using opioids , painkillers and sedatives regularely and in large doses.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Post Operative Pain. Timepoint: 2, 4, 6 and 8 hours after intervention. Method of measurement: VAS.	—

Secondary

Measure	Time frame
Nausea. Timepoint: 2 , 4 , 6 and 8 hours after intervention. Method of measurement: VAS.;Satisfaction. Timepoint: 2, 4, 6 and 8 hours after intervention. Method of measurement: VAS.;Pruritus. Timepoint: 2, 4, 6 and 8 hours after intervention. Method of measurement: yes or no.;Arterial Oxygen Desaturation. Timepoint: 2, 4, 6 and 8 hours after intervention. Method of measurement: Yes or no.;Changes in blood pressure. Timepoint: 2, 4, 6 and 8 hours after intervention. Method of measurement: In to three groups: Low, medium and high.;Changes in heart rate. Timepoint: 2, 4, 6 and 8 hours after intervention. Method of measurement: in to three groups : low , medium and high.	—

Measure

Time frame

Nausea. Timepoint: 2 , 4 , 6 and 8 hours after intervention. Method of measurement: VAS.;Satisfaction. Timepoint: 2, 4, 6 and 8 hours after intervention. Method of measurement: VAS.;Pruritus. Timepoint: 2, 4, 6 and 8 hours after intervention. Method of measurement: yes or no.;Arterial Oxygen Desaturation. Timepoint: 2, 4, 6 and 8 hours after intervention. Method of measurement: Yes or no.;Changes in blood pressure. Timepoint: 2, 4, 6 and 8 hours after intervention. Method of measurement: In to three groups: Low, medium and high.;Changes in heart rate. Timepoint: 2, 4, 6 and 8 hours after intervention. Method of measurement: in to three groups : low , medium and high.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Monadi Hamidfar

Qavin University of Medical sciences

Drmonadihamidfar@yahoo.com+98 26 3445 4321

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026