Comparing the clinical response of obsessive-compulsive patients refractory to serotonin reuptake inhibitor regimen with and without lamotrigine; a double-blind placebo controlled study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014031717045N1

Enrollment

Registered

2014-10-04

Start date

2014-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-compulsive patients. The essential feature is recurrent obsessional thoughts or compulsive acts.

Interventions

Intervention 1: Patients in intervention group continue the previous medication, Serotonin Reuptake Inhibitors, all over the study. Intervention group receive capsules containing lamotrigine, starting

Treatment - Drugs

Placebo

Patients in the placebo group continue previous medication, Serotonin Reuptake Inhibitors, all over the study. Patients in the placebo group receive one capsule daily. The number, shape and size of th

Patients in intervention group continue the previous medication, Serotonin Reuptake Inhibitors, all over the study. Intervention group receive capsules containing lamotrigine, starting at 25 mg daily,

Eligibility

Sex/Gender

All

Age

16 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:OCD diagnosis on axis I based on DSM IV TR; Ages between 16 and 60; Yale Brown Obsessive Compulsive Score of more than 21 Exclusion criteria: Active psychotic disorder such as schizophrenia, psychotic bipolar disorder and major depressive disorder; Major organic disorder; Organic brain disorder; Drug and substance abuse; Mental retardation; Pregnancy and lactation; During psychotherapy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Clinical response is measured by Yale Brown Obsessive Compulsive Scale. Timepoint: The day 0, 60 and 90. Method of measurement: Yale Brown Obsessive Compulsive Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSetareh Aram

Guilln University of Medical Sciences

Setareh.aramt@gmail.com+98 13 1666 2325

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026