Comparison of Midazolam and Propofol on nausea and vomiting induced during cesarean section with spinal anesthesia

Clinical trial of Comparison of low-dose Midazolam and Propofol on nausea and vomiting induced during operation, in pregnant women undergoing cesarean section with spinal anesthesia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014031717039N1

Enrollment

Registered

2014-07-30

Start date

2013-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea and vomiting. Postprocedural disorder of digestive system, unspecified

Interventions

Intervention 1: Patients were divided into two groups A and B randomly by Random Allocation software. They did not receive any special medicine before entering operation room. Before starting surgery,

Prevention

Patients were divided into two groups A and B randomly by Random Allocation software. They did not receive any special medicine before entering operation room. Before starting surgery, patients recei

Eligibility

Sex/Gender

Female

Age

15 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Written formal consent for operation, Pregnant women aged 15 to 60 years old, Class 1 and 2 ASA, Cesarean section candidate, No physical or mental illness, No consumption of Sedative, Antidepressant, Sleeping or Psychotropic medicine. Exclusion Criteria: Weight more than 100 kg, Age more than 60 or less than 15, Drug or alcoholic abusers, Treatment by Anti depressant, sleeping and psychotropic pills, Inadequate cooperation with investigator to assess nausea and vomiting after operation, Hospitalization in ICU after operation, Any background of Propofol or Midazolam sensitivity, Need for additional treatment, Becoming ill after surgery, Increased anesthesia level, Respiratory distress, Patients of class 3 and 4 of ASA, Hemodynamic disorders

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Nausea and Vomiting. Timepoint: 1 ,3, 5, 10, 15, 30 and 60 minutes after spinal anesthesia. Method of measurement: Have or not have with the Questionnaire made by Investigator.	—

Secondary

Measure	Time frame
Blood pressure. Timepoint: 1, 3, 5, 10, 15, 30 and 60 minutes after spinal anesthesia. Method of measurement: Sphygmomanometer.;Pulse. Timepoint: 1, 3, 5, 10, 15, 30 and 60 minutes after spinal anesthesia. Method of measurement: Pulse oximetry.;Respiratory Rate. Timepoint: 1, 3, 5, 10, 15, 30 and 60 minutes after spinal anesthesia. Method of measurement: Counting breaths by investigator.;O2 Saturation of arterial blood. Timepoint: During surgery and recovery. Method of measurement: Pulse oximetry.;Apgar. Timepoint: 1 and 5 minutes after the birth. Method of measurement: Assessment by investigator by Apgar criteria.	—

Measure

Time frame

Blood pressure. Timepoint: 1, 3, 5, 10, 15, 30 and 60 minutes after spinal anesthesia. Method of measurement: Sphygmomanometer.;Pulse. Timepoint: 1, 3, 5, 10, 15, 30 and 60 minutes after spinal anesthesia. Method of measurement: Pulse oximetry.;Respiratory Rate. Timepoint: 1, 3, 5, 10, 15, 30 and 60 minutes after spinal anesthesia. Method of measurement: Counting breaths by investigator.;O2 Saturation of arterial blood. Timepoint: During surgery and recovery. Method of measurement: Pulse oximetry.;Apgar. Timepoint: 1 and 5 minutes after the birth. Method of measurement: Assessment by investigator by Apgar criteria.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarjan Jaladat

Jahrom University of Medical Sciences

Marjan.Jaladat@gmial.com+98 79133404059

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026