Intrauterine growth restriction. Maternal care for known or suspected poor fetal growth
Conditions
Interventions
Intervention 1: Intervention group: 5 mg of Rosuvastatin (Poirsina company) once a day from the time of diagnosis until the time of delivery. Intervention 2: Control group: Placebo tablet made by the
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: singleton pregnancy Gestational age between 20 and 34 weeks The estimated gestational weight by ultrasound should be less than 3 percentile The estimated gestational weight by ultrasound is less than 10th percentile, which is associated with abnormal Doppler sonography Informed consent
Exclusion criteria
Exclusion criteria: Preeclampsia at the time of diagnosis Chromosomal disorder and anomaly Statin intolerance or allergy Acute pulmonary edema Liver disorder High blood pressure despite treatment Hellp syndrome Severe neurological symptoms Ductus venosus a- wave reversa
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The duration of pregnancy: the interval between the diagnosis of the disorder and the termination of pregnancy. Timepoint: From the time of starting the drug until the end of pregnancy. Method of measurement: Calculate the number of days.;Umbilical artery Doppler. Timepoint: Doppler ultrasound examination at the beginning of the study and then weekly until the end of the delivery. Method of measurement: Ultrasound.;Middle cerebral artery Doppler. Timepoint: Doppler ultrasound examination at the beginning of the study and then weekly until the end of the delivery. Method of measurement: Ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Birth weight. Timepoint: Birth. Method of measurement: scales.;Duration of hospitalization of the fetus in the neonatal intensive care unit. Timepoint: Discharge time from NICU. Method of measurement: number of days.;Apgar one and five minutes after the birth of the fetus. Timepoint: The first minute of birth and 5 minutes after birth. Method of measurement: special form. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFateme Askary
Shiraz University of Medical Sciences
Outcome results
None listed