Effect of Pentoxifiyllin on Fetal Growth Restriction

The effect of Pentoxifiylline administration on placenta circulation and pregnancy out come in Fetal Growth Restriction

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140317017034N9

Enrollment

Registered

2019-11-09

Start date

2019-11-22

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fetal Growth Restriction. Disorders of newborn related to slow fetal growth and fetal malnutrition

Interventions

Intervention 1: Intervention group: Pentoxifylline sustained release tablet 400 mg manufactured by Farabi Pharmaceutical Company twice daily until delivery. Intervention 2: Control group: Placebo twi

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Women with age under 45 Y/o Gestational age between 26-34 weeks Women with fetal growth restriction and abnormal finding in uterine or umbilical artery Doppler with stage 1, 2

Exclusion criteria

Exclusion criteria: High risk pregnancy (Multi fetal pregnancy; premature rupture of membrane; overt diabetes mellitus; Renal failure; preterm labor pain; rheumatoid disease eg:Lupus)) Bleeding disorders

Design outcomes

Primary

Measure	Time frame
Umbilical artery Doppler. Timepoint: Doppler ultrasound examination at the beginning of the study and then weekly until the end of the delivery. Method of measurement: Ultrasound.;Birth weight. Timepoint: After birth. Method of measurement: scale.;Appgar score. Timepoint: After birth. Method of measurement: Metric system.;Mean PH (Acid or Alkaline) of umbilical cord. Timepoint: After birth. Method of measurement: Blood-gaz-analyzer.;Uterine artery Doppler. Timepoint: Doppler ultrasound examination at the beginning of the study and then weekly until the end of the delivery. Method of measurement: Ultrasound.;Middle cerebral artery Doppler. Timepoint: Doppler ultrasound examination at the beginning of the study and then weekly until the end of the delivery. Method of measurement: Ultrasound.;Mean Carbon dioxide pressure of umbilical cord. Timepoint: After birth. Method of measurement: Blood-gaz-analyzer.;Mean Oxygen pressure of umbilical cord. Timepoint: After birth. Method of measurement: Blood-gaz-analyzer.;Mean Carbonic Acid of umbilical cord. Timepoint: After birth. Method of measurement: Blood-gaz-analyzer.	—

Measure

Time frame

Umbilical artery Doppler. Timepoint: Doppler ultrasound examination at the beginning of the study and then weekly until the end of the delivery. Method of measurement: Ultrasound.;Birth weight. Timepoint: After birth. Method of measurement: scale.;Appgar score. Timepoint: After birth. Method of measurement: Metric system.;Mean PH (Acid or Alkaline) of umbilical cord. Timepoint: After birth. Method of measurement: Blood-gaz-analyzer.;Uterine artery Doppler. Timepoint: Doppler ultrasound examination at the beginning of the study and then weekly until the end of the delivery. Method of measurement: Ultrasound.;Middle cerebral artery Doppler. Timepoint: Doppler ultrasound examination at the beginning of the study and then weekly until the end of the delivery. Method of measurement: Ultrasound.;Mean Carbon dioxide pressure of umbilical cord. Timepoint: After birth. Method of measurement: Blood-gaz-analyzer.;Mean Oxygen pressure of umbilical cord. Timepoint: After birth. Method of measurement: Blood-gaz-analyzer.;Mean Carbonic Acid of umbilical cord. Timepoint: After birth. Method of measurement: Blood-gaz-analyzer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactShohreh Roozme

Shiraz University of Medical Sciences

dr.roozmeh1995@yahoo.com+98 71 3612 8258

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026