Effect of Pentoxifiyllin on Fetal Growth Restriction

The effect of Pentoxifiylline administration on placenta circulation and pregnancy out come in Fetal Growth Restriction

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140317017034N8

Enrollment

Registered

2019-10-18

Start date

2019-08-23

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fetal Growth Restriction. Disorders of newborn related to slow fetal growth and fetal malnutrition

Interventions

Intervention 1: Intervention group: Pentoxifylline sustained release tablet 400 mg manufactured by Farabi Pharmaceutical Company twice daily for 14-28 days. Intervention 2: Control group: Placebo twic

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Women with age under 45 Y/o Gestational age between 26-34 weeks Women with fetal growth restriction and abnormal finding in uterine or umbilical artery Doppler with stage 1, 2

Exclusion criteria

Exclusion criteria: High risk pregnancy (Multi fetal pregnancy; premature rupture of membrane; overt diabetes mellitus; Renal failure; preterm labor pain; rheumatoid disease eg:Lupus) Bleeding disorders

Design outcomes

Primary

Measure	Time frame
Measuring the serum level of TNF a. Timepoint: Before and after intervention. Method of measurement: Kit.;Measuring the serum level of LI 1. Timepoint: Before and after intervention. Method of measurement: Kit.;Measuring the serum level of sflt-1. Timepoint: Before and after intervention. Method of measurement: Kit.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShiraz University of Medical Sciences

Shiraz University of Medical Sciences

dr.roozmeh1995@yahoo.com+98 71 3612 8258

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026