Fetal Growth Restriction. Disorders of newborn related to slow fetal growth and fetal malnutrition
Conditions
Interventions
Intervention 1: Intervention group: In the case group Intrauterine exosomes transfusion [100 µ per fetal weight (Kg) in 2 dosages apart one week] was done via umbilical vein like a routine method for
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Stage II, III of early-onset FGR between 24-32 WKS
Exclusion criteria
Exclusion criteria: Major anatomical abnormalities during anomaly scan Genetic disorders in amniocentesis report Fetal infection-Maternal comorbid disease Premature rupture of membrane, active preterm labor Maternal active viral disease Multiple pregnancy vaginal bleeding Gestational age below 24 wks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biometry fetal(fetal weight, Utero-fetal-placental Dopplers, amniotic fluid index). Timepoint: weekly. Method of measurement: Sonography.;NICU admission. Timepoint: After birth. Method of measurement: clinical.;Neurological development. Timepoint: at 6-month-old. Method of measurement: ASQ form.;Placental growth factor (PLGF). Timepoint: before and after treatment. Method of measurement: Kit.;Microscopic and macroscopic placental pathology. Timepoint: After delivery. Method of measurement: Clinical and laboratory (microscope).;Apgar score. Timepoint: After birth. Method of measurement: Clinical.;Soluble fms-like tyrosine kinase receptor-1 (sFlt-1) factor. Timepoint: before and after treatment. Method of measurement: Eliza kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShohreh Roozmeh
Shiraz University of Medical Sciences
Outcome results
None listed