Effects of pomegranate juice on osteoarthritis of the knee

Assessing the effects of pomegranate juice consumption on clinical signs, matrix metalloproteinase 13 & glutathione peroxidase in patients with osteoarthritis of the knee.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014031517017N1

Enrollment

Registered

2014-11-21

Start date

2014-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis. Gonarthrosis [arthrosis of knee]

Interventions

Intervention 1: Intervention group: Daily consumption of 200 ml pomegranate juice produced by Takdaneh company for 6 weeks in intervention group. Intervention 2: Control group: No intervention will do

Treatment - Other

Intervention group: Daily consumption of 200 ml pomegranate juice produced by Takdaneh company for 6 weeks in intervention group

Control group: No intervention will do in control group.

Eligibility

Sex/Gender

All

Age

30 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age:30-80 yrs; diagnosis of osteoarthritis of the knee by a rheumatologist according to ACR criteria ( based on pain history, physical examination, laboratory and radiological findings); ability to drink pomegranate juice and no allergy to this. Exclusion criteria: patients with inflammatory diseases; rheumatoid arthritis; diabetes mellitus; cardiovascular diseases; liver diseases; renal diseases; cancer; who treated with oral corticosteroids in the last 4 weeks; who injected corticosteroids in the last 6 months; antioxidants consumption and pregnancy.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: before and after the intervention. Method of measurement: WOMAC questionnair.;Stiffness. Timepoint: before and after the intervention. Method of measurement: WOMAC questionnair.;Physical function. Timepoint: before and after the intervention. Method of measurement: WOMAC questionnair.	—

Secondary

Measure	Time frame
Sreum mmp13. Timepoint: before and after the intervention. Method of measurement: before and after the intervention.;Serum glutathione peroxidase. Timepoint: before and after the intervention. Method of measurement: before and after the intervention.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNasrin Ghoochani

Nutrition & Metabolic Diseases Research Center , Ahvaz Jundishapur University of Medical Sciences

n_ghoochani@yahoo.com+98 61 3373 8253

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026