Nasal polyposis. nasal polyp, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Furosemide/ spray/ twice a day/ 2puffs in each nostril for 2 months. Intervention 2: Control group: placebo/ spray/ twice a day/ 2 puff in each nostril for 2 month
Prevention
Placebo
Intervention group: Furosemide/ spray/ twice a day/ 2puffs in each nostril for 2 months.
Control group: placebo/ spray/ twice a day/ 2 puff in each nostril for 2 months.
Sponsors
Hamedan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients referred to Besat hospital clinic with chronic rhinosinusitis (according to AAO-HNS) who have not responded to medical therapy and age with 18-60 years old. Exclusion criteria: pregnancy; history of hypertension? cardiac diseases? hypokalemia; history of tinnitus; history of sensory neural hearring loss and hypersensitivity to furosemide.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nasal and paranasal sinus polyposis. Timepoint: Before intervention,1 month, 3 months, 6 months after intervention. Method of measurement: SNOT-22 questionnaire, PNS CT scan scoring, VAS, Meltzer grading. | — |
Secondary
| Measure | Time frame |
|---|---|
| Burning sensation. Timepoint: 1 month, 3 months, 6 months after intervention. Method of measurement: Questionnaire.;Epistaxis. Timepoint: 1 month, 3 months, 6 months after intervention. Method of measurement: Questionnaire and physical examinatin.;Hypersensitivity. Timepoint: 1 month, 3 months, 6 months after intervention. Method of measurement: Questionnaire and physical examinatin. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarnaz Hashemian
Hamedan University of Medical Sciences
Outcome results
None listed