Controlled trial of comparison of the effect of controlled ovarian stimulation protocols on gene expression of germinal vesicle oocytes in infertile women

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014031112307N3

Enrollment

Registered

2014-04-21

Start date

2012-09-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Contrlled Ovarian Stimulation protocols. Female infertility

Interventions

Intervention 1: Control group: In the gonadotropin releasing hormone agonist long protocol group, the administration of Buserelin acetate 500 µg/d is started subcutaneously proceeding the IVF cycle fr

Treatment - Drugs

Control group: In the gonadotropin releasing hormone agonist long protocol group, the administration of Buserelin acetate 500 µg/d is started subcutaneously proceeding the IVF cycle from day 21 until

Intervention group: In the gonadotropin releasing hormone antagonist fixed multi-dose protocol group, Cetrorelix acetate 0.25 mg/day subcutaneously is initiated on the sixth day of the gonadotropin st

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age 18-40 years; normal serum level of steroidal hormones; male infertility, tubal factor infertility and unexplained infertility. Exclusion criteria: genetic diseases; moderate or severe endometriosis and poly cystic ovarian.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Determination of the effect of controlled ovarian stimulation protocols on gene expression of germinal vesicle oocytes in infertile women. Timepoint: ?End of sampling. Method of measurement: Real Time PCR.	—

Secondary

Measure	Time frame
Determination of the effect of controlled ovarian stimulation protocols on adenosine triphosphatase 6 gene expression of human germinal vesicle oocytes. Timepoint: The end of sampling. Method of measurement: Real Time PCR.;Determination of the effect of controlled ovarian stimulation protocols on growth differentiation factor 9 gene expression of human germinal vesicle oocytes. Timepoint: The end of sampling. Method of measurement: Real Time PCR.;Determination of the effect of controlled ovarian stimulation protocols on bone morphogenetic protein15 gene expression of human germinal vesicle oocytes. Timepoint: The end of sampling. Method of measurement: Real Time PCR.;Determination of the effect of controlled ovarian stimulation protocols on neuronal apoptosis inhibitory protein gene expression of human germinal vesicle oocytes. Timepoint: The end of sampling. Method of measurement: Real Time PCR.	—

Measure

Time frame

Determination of the effect of controlled ovarian stimulation protocols on adenosine triphosphatase 6 gene expression of human germinal vesicle oocytes. Timepoint: The end of sampling. Method of measurement: Real Time PCR.;Determination of the effect of controlled ovarian stimulation protocols on growth differentiation factor 9 gene expression of human germinal vesicle oocytes. Timepoint: The end of sampling. Method of measurement: Real Time PCR.;Determination of the effect of controlled ovarian stimulation protocols on bone morphogenetic protein15 gene expression of human germinal vesicle oocytes. Timepoint: The end of sampling. Method of measurement: Real Time PCR.;Determination of the effect of controlled ovarian stimulation protocols on neuronal apoptosis inhibitory protein gene expression of human germinal vesicle oocytes. Timepoint: The end of sampling. Method of measurement: Real Time PCR.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Seyed Mohammad Hossein Noori Mugahi

Tehran University of Medical Sciences

Noorimoo@sina.tums.ac.ir+98 21 8895 3008

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026