Evaluation of efficacy of sodium valproate in cervical and lumbar radicular pain management

Evaluation of efficacy of sodium valproate low dose in cervical and lumbar radicular pain management and it’s relation with pharmacokinetic properties

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201403101836N8

Enrollment

Registered

2014-03-18

Start date

2014-04-05

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cervical and lumbar radicular pain.

Interventions

Intervention 1: Control group: placebo. Intervention 2: Intervention group: sodium valproate, 200 mg, once a day for 10 days.

Placebo

Treatment - Drugs

Control group: placebo

Intervention group: sodium valproate, 200 mg, once a day for 10 days.

Eligibility

Sex/Gender

All

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. Diagnosis of lumbar or cervical radicular pain based on diagnostic of rheumatology specialist. 2. Age between 30 and 60 years. 3. Patients will included if they don’t have possibility of health risk or confounding by other diseases of syndromes, e.g., pregnancy, thyroid disorders, hepatic or kidney disorders, congestive heart failure and diabetes mellitus. 4. Patients havent used sodium valproate or if they have been using, they must remember pain intensity before using sodium valproate and can compare with current pain intensity. 5. Weight between 60 and 90 kg. Exclusion criteria: 1. Intolerance to sodium valproate side effects. 2. Patients will be forced to administerated medicines that change protein binding or clearance of sodium valproate. 3. Patients will be given diseases that affect the results of study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain intensity. Timepoint: Before intervention, 10 days after beginning of intervention. Method of measurement: Visual analog scale.;Number of acetaminophen administration. Timepoint: 10 days after beginning of intervention. Method of measurement: Empty acetaminophen blister which will be recieved by patients.	—

Secondary

Measure	Time frame
Serum concentration of sodium valproate. Timepoint: 10 days after beginning intervention. Method of measurement: Gas chromatography with flame ionization detector.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Mojtaba Sohrevardi

Faculty of Pharmacy- Shahid Sadoughi University of Medical Sciences

smsohrevardi@ssu.ac.ir+98 35 1820 3410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026