Assessment of Aminophylline on decreasing recovery time after general anesthesia

Assessment of different doses of aminophylline on decreasing recovery time and EEG during recovery based on BFI (Brain Function Index) after Isoflurane anesthesia in Trunk surgery.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201403073773N11

Enrollment

102

Registered

2015-08-02

Start date

2014-04-04

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: brain signals. Condition 2: Recovery time. Other specified disorders of central nervous system Disorder of central nervous system, unspecified

Interventions

Intervention 1: In group 1, after cleaning of forehead with alcohol and adhesion of leads, EEG monitoring started based on BIS. All patients received midazolam 60 mic g/kg and fentanyl 2 mic g/ kg as

Placebo

In group 2, after cleaning of forehead with alcohol and adhesion of leads, EEG monitoring started based on BIS. All patients received midazolam 60 mic g/kg and fentanyl 2 mic g/ kg as pre-medication.

In group 3, after cleaning of forehead with alcohol and adhesion of leads, EEG monitoring started based on BIS. All patients received midazolam 60 mic g/kg and fentanyl 2 mic g/ kg as pre-medication.

In group 1, after cleaning of forehead with alcohol and adhesion of leads, EEG monitoring started based on BIS. All patients received midazolam 60 mic g/kg and fentanyl 2 mic g/ kg as pre-medication.

Eligibility

Sex/Gender

All

Age

15 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients undergoing elective Trunk surgery with general anesthesia ;patients with ASA, class 1 & 2;patients between 15 to 70 years old;weight more than 40 kg.Exclusion criteria :patients with asthma ( or similar diseases) in whom aminophylline is needed during surgery or during recovery; patients with liver failure or cardiac failure ( cor pulmonale);neurologic or psychologic diseases which can cause seizure;drugs which affect brain activity including tranquilizers and CNS stimulants (eg. Amphetamine);serum albumin less than 2gr/dl ( which lowers drug- plasma protein binding and increases drug effects);aminophylline injection during surgery for any reason;labetalol or other similar drugs injection (affecting cardiovascular system) during surgery for any reason.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Patient's stay time at PACU (Post Anesthesia Care Unit). Timepoint: From discontinuing of anesthesia till discharge of PACU. Method of measurement: minute.	—

Secondary

Measure	Time frame
Brain signals. Timepoint: During anesthesia and recovery time. Method of measurement: BFI (Brain Function Index).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Farsad Imani

Tehran University of Medical Sciences

imanifar@tums.ac.ir+98 21 63120

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026