Effect of probiotic Lactobacillus reuteri on enteral feeding in premature infants

Effect of dietary supplementation of probiotic Lactobacillus reuteri on gastrointestinal complications of enteral feeding in premature infants with low birth weight

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014030716870N1

Enrollment

Registered

2014-04-17

Start date

2012-08-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premature infant. 28 completed weeks or more but less than 37 completed weeks

Interventions

Intervention 1: probiotic group was prescribedone 1drop/kg probiotic supplemental orally with 0.5 ml distilled water every 12 hours. Intervention 2: The placebo group was received 0.5 ml of distilled

Treatment - Drugs

probiotic group was prescribedone 1drop/kg probiotic supplemental orally with 0.5 ml distilled water every 12 hours.

The placebo group was received 0.5 ml of distilled water every 12 hours and cure was continued to reach full enteral

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criterion: prematurity with birth weight 1000-1800 g. Exclusion criteria: digestive obstruction; abdominal distension; gastrointestinal bleeding; gastroschisis, emphalocele; withdrawal syndrome; clinical or proven sepsis; congenital heart diseases and II and III degree of asphyxia.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Enteral feeding hang time. Timepoint: Daily. Method of measurement: Daily milk volume of 120 ml / kg/day.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKhadijeh Nasiriani

Shahid Sadoughi University of Medical Sciences

asiriani@gmail.com; nasiriani@ssu.ac.ir+98 35 1824 1755

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026