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Thiamine ( Intravenous Vitamin B1) induced post–operative analgesia in maxillofacial surgery.

Role of thiamine in the management of post–operative analgesia in maxillofacial surgery.

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201403061674N11
Enrollment
50
Registered
2014-07-03
Start date
2014-08-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Maxillofacial surgery. 00

Interventions

Intervention 1: Patients in the interventional group (first group) will be received an intravenous "Thiamine hydrochloride" 200 mg dissolved in Dextrose Water 5% via pump infusion bolus for 15 min. I
Treatment - Drugs
Patients in the interventional group (first group) will be received an intravenous "Thiamine hydrochloride" 200 mg dissolved in Dextrose Water 5% via pump infusion bolus for 15 min.
Patients in the the second group will receive " placebo" as same bolus volume of " Dextrose Water 5% " in a 15-minute intravenous infusion.

Sponsors

Vice-Chancellery of Research and Technology, Shiraz University Of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria included: The patients with systemic disease and no history of drug use, and willingness to cooperate in this study are enrolled? Exclusion criteria included known allergy to the study drug, hepatic and renal dysfunction and lack of signed informed consent will be excluded.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Intensity of postoperative pain. Timepoint: Immediately after surgery to 12 hours after surgery. Method of measurement: VAS.;Use of narcotic after surgery. Timepoint: To 12 hours after surgery. Method of measurement: Nursing reports.

Secondary

MeasureTime frame
Post-operative complications of Thiamine. Timepoint: Immediately after surgery to 12 hours after surgery. Method of measurement: Nursing reports.;Patient's level of satisfaction. Timepoint: Immediately after surgery to 12 hours after surgery. Method of measurement: poor (0), moderate (1), good (2), and excellent (3).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamid Reza Eftekharian

Shiraz Chamran Hospital

eftekharhr@sums.ac.ir+98 71 1624 0105

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026