The effect of religious cognitive- behavioral therapy ,classic cognitive- behavioral therapy and Citalopram on anxiety, depression , related biomarkers and quality of life of breast cancer patients.

Comparison of effect of religious cognitive- behavioral therapy ,classic cognitive- behavioral therapy and Citalopram on anxiety, depression , related biomarkers and quality of life of breast cancer patients. patients.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201403042898N4

Enrollment

200

Registered

2014-05-24

Start date

2014-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxiety, Depression, related biomarkres, Quality of life. Organic anxiety disorder,Depressive episode

Interventions

Intervention 1: Religious cognitive behavioral therapy(intervention group )12one hour psychological session and usual treatment. Intervention 2: Classic cognitive behavioral therapy (interventi

Behavior

Treatment - Drugs

Treatment - Other

Religious cognitive behavioral therapy(intervention group )12one hour psychological session and usual treatment

Classic cognitive behavioral therapy (intervention group ) 12 one hour psychological session and usual treatment

Citalopram (intervention group ) 20-40 mg for 3 month and usual treatment

usual treatment: ( Control group ) usual treatment due to physical and psychological outcome in breast cancer treatment.

Eligibility

Sex/Gender

Female

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Women with breast cancer who referring to Tuba Clinic for follow up, aged 18-65, being at stages 1 and 2, and having undergone surgery, chemotherapy, or radiotherapy,being able to communicate, speak Farsi, and having an education level of higher than junior high school, obtaining the score of 8 or more in depression and anxiety based on HADS questionnaire,no evidence of psychiatric disorders including schizophrenia, bipolar, and serious suicide thoughts based on the clinical interview (DSM-IV) that will be done by a psychiatrist, no evidence of severe physical conditions ( other malignancies ) preventing them from attending the treatment sessions , getting the score of 25 and more from Golriz and Baraheni’s religious attitude questionnaire, Exclusion criteria:Having the experience of taking part in religious cognitive- behavioral therapy or classic cognitive- behavioral therapy courses and taking Citalopram or other drugs in the routine treatment due to their psychological problems at least two weeks ago.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Anxiety. Timepoint: Before intervention ,3,6,9 and 12 month after intervention. Method of measurement: Hospital Anxiety Deprestion Questionnaire(HADS).;Depression. Timepoint: Before intervention ,3,6,9 and 12 month after intervention. Method of measurement: Hospital Anxiety Deprestion Questionnaire (HADS).	—

Secondary

Measure	Time frame
Improving the quality of life. Timepoint: Before intervention ,3,6,9 and 12 month after intervention. Method of measurement: BR-23 , EORTCQLQ-C30 questionnaire.;To become normal level of biomarkers( ?L6 ??L10 ? DHEA ?cortisol ? IFN? ? TNFa). Timepoint: Before intervention ,3and 12 month after intervention. Method of measurement: ELISA.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Hamzeh Hosseini

Mazandaran University of Medical Sciences

shhosseini@mazums.ac.ir+98 15 1328 3886

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026