Diabet mellitus. non insulin dependent diabetes mellitus
Conditions
Interventions
Intervention 1: The first group (group A) uses placebo metformin and placebo Acarbose. Intervention 2: The second group (group B) takes 500-mgl metformin pills every night
the drug dose increases for 2 grams every week, and they also use placebo Acarbose. Intervention 3: The third group (group C) use 100 mg of Acarbose pill. The dose in the first week is 50 and then 100
they also use metformin placebo. Intervention 4: The fourth group (group D) uses metformin and Acarbose pill.
Placebo
Treatment - Drugs
The first group (group A) uses placebo metformin and placebo Acarbose
The second group (group B) takes 500-mgl metformin pills every night
the drug dose increases for 2 grams every week, and they also use placebo Acarbose.
The third group (group C) use 100 mg of Acarbose pill. The dose in the first week is 50 and then 100 mg for each meal (utmost daily doze is 300 mg)
they also use metformin placebo.
The fourth group (group D) uses metformin and Acarbose pill.
Sponsors
Physiology research center, Vice chancellor for Research and Technology of kerman medical University
Excir company
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Type 2 diabetes (based on American Diabetes Association criteria) 2. age group 18-75 years 3. Enough acuity and alertness to injection of insulin 4. no glycemic control with oral medications Exclusion criteria: 1. Chronic Complications of Diabetes 2. Pregnancy 3. Breastfeeding 4. Liver Disease 5. kidney disease 6. neurological disease 7. chronic inflammatory disease
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma glucose. Timepoint: During of study. Method of measurement: Blood sample.;HbA1c. Timepoint: 0, 90. Method of measurement: Blood sample.;Hypoglycemia. Timepoint: Self - monitoring of blood glucose. Method of measurement: Questionnaire and blood tests during raid. | — |
Secondary
| Measure | Time frame |
|---|---|
| Laboratory Tests. Timepoint: Before and one month, two months, three months after the intervention. Method of measurement: blood and urine sample.;Weight and blood prussre and others. Timepoint: Before and one month, two months, three months after the intervention. Method of measurement: Barometer system and standard weight. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mojgan Sanjari
Associated professor
Outcome results
None listed