The Effect Of Midazolam, Ketamine, Isoflurane And Remifentanil On Postoperative Pain After Rhinoplasty

Comparison Of Infusion Of Midazolam-Ketamine With Isofloran-Remifentanil On Postoperative Pain In Patients Undergoing Rhinoplasty Surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014030116119N2

Enrollment

Registered

2014-11-01

Start date

2014-07-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Analgesia. complication of medical and surgical care-opioids and related analgesics

Interventions

Intervention 1: Group1: maintenance of anesthesia with infusion 30-45 mcg/kg/min ketamine and 1.3 mcg/kg/min midazolam and ventilation with 50% nitrous oxide. Intervention 2: Group2: maintenance of a

Prevention

Group1: maintenance of anesthesia with infusion 30-45 mcg/kg/min ketamine and 1.3 mcg/kg/min midazolam and ventilation with 50% nitrous oxide

Group2: maintenance of anesthesia with 1 mac isoflurane and ventilation with 50% nitrous oxide and infusion 1-2 mcg/kg/min remifentanil

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: No history of renal, cardiac, hepatic diseases. Exclusion criteria: The control problem of anesthesia during surgery; history of allergy to drugs used during surgery; prolonged surgery; changing the operation to another type of surgery except rhinoplasty

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: in the recovery room and 2,4 ,8 ,16 and 24 hours after surgery. Method of measurement: visual analog scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Akhondzadeh

Imam Khomeini Hospital

rezaakh@hotmail.com00

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026