Skip to content

Comparison the effect of Letrozole plus Misoprostol and Misoprostol alone in termination of nonviable first trimester pregnancies

Comparison the effect of Letrozole plus Misoprostol and Misoprostol alone in termination of nonviable first trimester pregnancies; A single Blinded Randomized Trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014030114293N1
Enrollment
124
Registered
2014-03-14
Start date
2014-03-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Therapeutic Abortion. Medical abortion : incomplete, without complication

Interventions

Intervention 1: Intervention group: 10 mg (4 tablets 2.5 mg) letrozole for 3 days and after 3 days, 600 mcg (3 tablets of 200 mcg) of misoprostol as single dose. Intervention 2: Control group: 600 mcg
Treatment - Drugs
Intervention group: 10 mg (4 tablets 2.5 mg) letrozole for 3 days and after 3 days, 600 mcg (3 tablets of 200 mcg) of misoprostol as single dose.
Control group: 600 mcg (3 tablets 200 mcg) as a single dose.

Sponsors

?Women's Reproductive Health Research Center
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Main inclusion criteria: over age 18 pregnant women with nonviable pregnancy under 12 weeks on the first day of the last menstrual without other systemic problems. Main exclusion criteria: acute illness that requires any urgent intervention and treatment.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Abortion Rate. Timepoint: Two weeks after intervention. Method of measurement: Ultrasonography.

Secondary

MeasureTime frame
Gastrointestinal problems. Timepoint: From intervention to abortion time. Method of measurement: Clinical exam.;Decrease in hemoglobin. Timepoint: Just before intervention and two weeks later. Method of measurement: Laboratory.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParia Sadeghi Shabestari

Tabriz university of medical sciences\ Al-Zahra hospital

psmed382@yahoo.com+98 41 1553 9161

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026