Effect of oral gabapentin versus placebo on pain relief after gynecologic surgery

Effect of oral gabapentin versus placebo on pain relief after gynecologic surgery: a triple blinded randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201402289014N28

Enrollment

102

Registered

2014-05-26

Start date

2014-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain at surgical site at inguinal area. Pain localized to other parts of lower abdomen

Interventions

Intervention 1: 34 patients will receive two gabapentin capsules 300 mg (600 mg) single dose 2 hours before surgery. Intervention 2: 34 patients will receive one gabapentin capsule 300 mg plus one pla

Treatment - Drugs

Placebo

34 patients will receive two gabapentin capsules 300 mg (600 mg) single dose 2 hours before surgery

34 patients will receive one gabapentin capsule 300 mg plus one placebo capsule (containing starch) single dose 2 hours before surgery

34 patients will receive two placebo capsules (containing starch) single dose 2 hours before surgery

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: (a) age of 18 to 65 years; (b) women with physical class ASA I-II; (c) candidate for elective gynecologic surgery. Exclusion criteria: (a) contraindication for neuroaxial anesthesia; (b) history of hypertension or diabetes mellitus; (c) using narcotics or psychotropic.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain at the surgical site. Timepoint: at 1, 6, 12, 18, 24, and 48 hours after surgery. Method of measurement: using VAS scale.;The amount of narcotic used. Timepoint: during the first 48 hours after surgery. Method of measurement: per mg.;The duration of time to receive narcotic. Timepoint: during the first 48 hours after surgery. Method of measurement: per min.	—

Secondary

Measure	Time frame
Vertigo. Timepoint: at 1, 6, 12, 18, 24, and 48 hours after surgery. Method of measurement: by question.;Nausea and vomiting. Timepoint: at 1, 6, 12, 18, 24, and 48 hours after surgery. Method of measurement: by question.;Pruritus. Timepoint: at 1, 6, 12, 18, 24, and 48 hours after surgery. Method of measurement: by question.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Parisa Shirzad

Beasat Hospital

shirzad.parisa7@gmail.com+98 81 1341 6392

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026