Necrotizing enterocolitis. Necrotizing enterocolitis of fetus and newborn
Conditions
Interventions
Placebo
Intervention 1: Intervention group: When volume of feeding reaches to 5cc/kg/day, 1 drop/kg of oral probiotics drop (Pedilact, Sepehr Pharmaceutics, Iran) diluted with normal saline to 0.5cc will be a
Prevention
Intervention group: When volume of feeding reaches to 5cc/kg/day, 1 drop/kg of oral probiotics drop (Pedilact, Sepehr Pharmaceutics, Iran) diluted with normal saline to 0.5cc will be administered each
Control group: 0.5 cc of normal saline (Samen Pharmaceutics, Iran) will be administered each 12 hours when volume feeding reaches to 5 cc/kg/day.
Sponsors
Vice Chancellor for research, Shahid Sadoughi University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Days to 3 Months
Inclusion criteria
Inclusion criteria: Inclusion criteria: Neonates with gestational age <36 weeks; Birth weight 1000-2500 grams and admitted in NICU ward of the Shahid Sadughi hospital; Yazd Exclusion criteria: Neonates with obstruction of gasterointestinal; Congenital heart disease; Omphalocele; Gasterochesia; Asphyxia (grade II,III)and Addiction of mother.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Necrotizing enterocolitis. Timepoint: During intervention. Method of measurement: Bell staging criteria. | — |
Secondary
| Measure | Time frame |
|---|---|
| When full enteral feeding is reached. Timepoint: During intervention. Method of measurement: Per day.;Weight of neonate at the time of discharged. Timepoint: When the neonate is discharged. Method of measurement: With scale(seca).;During hospitalization. Timepoint: When the neonate is discharged. Method of measurement: Per day.;Mortality. Timepoint: During intervention. Method of measurement: Per person. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFateme Naghibifard
Shahid Sadoughi Hospital
Outcome results
None listed