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Effect of Sildenafil on Endometriosis dysmenorrhea

Evaluation of sildenafil on dysmenorhea in patients with endometriosis compared to placebo

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20140227016765N5
Enrollment
40
Registered
2018-10-26
Start date
2018-06-22
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

endometriosis. endometriosis

Interventions

Intervention 1: Intervention group: using daily sildenafil, 100 mg tablet, during 3 days of menstrual cycle. Intervention 2: Control group: using daily placebo tablet, similar to sildenafil, during 3

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: patients with moderate to severe endometriosis suffer from dysmenorrhea, They are between 18 and 45 years old They were diagnosed with ultrasound

Exclusion criteria

Exclusion criteria: People who take nitroglicerine during study People who have used any hormonal medication People with hepatorenal disease People with pelvic pain non relevant to menstural cycle People with pervious MI or CVA People with abnormal blood pressure People with PID People with malignancies People with acute eye problem

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: Before and 1, 2 and 3 hours after the intervention. Method of measurement: VAS questionnaire.

Secondary

MeasureTime frame
The amount of pain-relieving use during the study. Timepoint: At the end of the study. Method of measurement: questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Tavoli

Tehran University of Medical Sciencers

ztavoli@tums.ac.ir+98 21 7771 5342

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026