Effect of oral contraception tablets on metabolism. Surveillance of contraceptive drugs
Conditions
Interventions
Intervention 1: Intervention group: tablet of contraceptive DE with trade name of Marolin made by Aburaihan Pharmaceutical Company in Tehran, containing 30 micrograms Ethinyl Estradiol and 150 microg
Prevention
Intervention group: tablet of contraceptive DE with trade name of Marolin made by Aburaihan Pharmaceutical Company in Tehran, containing 30 micrograms Ethinyl Estradiol and 150 micrograms Desogestrel
Control group: tablet of contraceptive LD with trade name of Ovocept LD made by Aburaihan Pharmaceutical Company in Tehran, containing 30 micrograms Ethinyl Estradiol and 150 micrograms Levonorgestrel
Sponsors
Research deputy of Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: married women; having regular, spontaneous menstrual cycles varying from 21 to 35 days; body mass index between 25 and 34.9 kilograms per square meter; fasting blood glucose lower than 126 milligrams per deciliter; blood glucose after 2-hour glucose tolerance test lower than 200 milligrams per deciliter; low density lipoprotein lower than 160 milligrams per deciliter; triglycerides lower than 250 milligrams per deciliter; having a desire to participate in the study Exclusion criteria: having absolute and relative contraindications of combined oral contraceptives; using hormonal contraceptive methods during the last 3 months; taking lipid lowering drugs such as lovastatin, Gemfibrozil, Atorvastatin, Cholestyramine, etc; having thyroid and renal diseases
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting blood glucose. Timepoint: Before the intervention and three months after intervention. Method of measurement: Spectrophotometric technique.;Total cholesterol. Timepoint: Before the intervention and three months after intervention. Method of measurement: Spectrophotometric technique.;Low density lipoprotein. Timepoint: Before the intervention and three months after intervention. Method of measurement: Spectrophotometric technique.;High density lipoprotein. Timepoint: Before the intervention and three months after intervention. Method of measurement: Spectrophotometric technique. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood glucose after 2-hour 75 gram oral glucose tolerance test. Timepoint: Before the intervention and three months after intervention. Method of measurement: Spectrophotometric technique.;Triglycerides. Timepoint: Before the intervention and three months after intervention. Method of measurement: Spectrophotometric technique. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSamira Pourzeinali Beilankooh
Tabriz University of Medical Sciences
Outcome results
None listed