infertility. Female infertility associated with anovulation
Conditions
Interventions
Intervention group: The patient were treated by letrozole at 7.5 mg/day (Saha pharmaceutical company) and Gonal-f at 225 mg/day (Merck pharmaceutical company), started on the 2nd-3rd day of menstrual
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 42 Years
Inclusion criteria
Inclusion criteria: women with poor ovarian response that at least two of the following three features(Bologna criteria) must be present: (i) advanced maternal age or any other risk factor for POR; (ii) a previousPOR; and (iii) an abnormal ovarian reserve test. age 18-42 years previous poor ovarian response(oocyte<3) to ovarian stimulation by gonadotropin.
Exclusion criteria
Exclusion criteria: metabolic disease (diabetes, chronic hypertension, etc) or any underlying disease ( kidney disease, liver disease, etc.) presence cancer or any malignancy genitourinary anomalies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of oocytes achieved after letrozole+gonadotropine regimen. Timepoint: after ovarian puncture. Method of measurement: reporting by embryology laboratory.;Mean endometrial thickening after letrozole+gonadotropin regimen. Timepoint: at injection day of HCG. Method of measurement: ultrasound sonography.;Rate of pregnancy after letrozole+gonadotropin regimen. Timepoint: 2weeks after ovarian puncture. Method of measurement: level of beta human chorionic gonadotropin in a sample of blood. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNegar Hamzehpour
Shahid Beheshti University of Medical Sciences
Outcome results
None listed