The effects of Nicotinic acid on serum phosphorus, PTH and lipid profile in dialysis patients .

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201402212954N4

Enrollment

120

Registered

2014-04-12

Start date

2014-03-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Hyperphosphatemi. Condition 2: Hyperlipidaemia. Condition 3: Hyperparathyroidism. Disorder of phosphorus metabolism Mixed hyperlipidaemia Hyperparathyroidism and other disorders of parathyroid gland

Interventions

Intervention 1: Intervention group (Group I) will receive nicotinic acid . Nicotinic acid will be started as 200 mg/day, patients will be controlled for nicotinic acid's side effects such as GI proble

Treatment - Drugs

Placebo

Intervention group (Group I) will receive nicotinic acid . Nicotinic acid will be started as 200 mg/day, patients will be controlled for nicotinic acid's side effects such as GI problems and thrombocy

Intervention group (Group II) will receive placebo similar case group and will continue till 12 weeks.

Eligibility

Sex/Gender

All

Age

15 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age > 15 & 550 ug/ml; TG >350mg/ml; LDL>150mg/ml and HDL<25 mg/ml; unchanged treatment protocol; (calcium components and Vit D) during last two weeks; unchanged dialysis protocol. Exclusion criteria: pregnancy; known liver disease; active peptic ulcer; carbamazepine use; drug intolerance and not satisfaction of patients.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum phosphate level. Timepoint: Twice a weeks for 3 months. Method of measurement: By standard kit in Imam Hossein hospital.;PTH level. Timepoint: Monthly for 3 months. Method of measurement: By standard kit in Imam Hossein hospital.;TG level. Timepoint: Start and end in 3 months. Method of measurement: By standard kit in Imam Hossein hospital.;LDL level. Timepoint: Start and end in 3 months. Method of measurement: By standard kit in Imam Hossein hospital.;HDL level. Timepoint: Start and end in 3 months. Method of measurement: By standard kit in Imam Hossein hospital.	—

Measure

Time frame

Serum phosphate level. Timepoint: Twice a weeks for 3 months. Method of measurement: By standard kit in Imam Hossein hospital.;PTH level. Timepoint: Monthly for 3 months. Method of measurement: By standard kit in Imam Hossein hospital.;TG level. Timepoint: Start and end in 3 months. Method of measurement: By standard kit in Imam Hossein hospital.;LDL level. Timepoint: Start and end in 3 months. Method of measurement: By standard kit in Imam Hossein hospital.;HDL level. Timepoint: Start and end in 3 months. Method of measurement: By standard kit in Imam Hossein hospital.

—

Secondary

Measure	Time frame
Serum Calsium level. Timepoint: Twice a weeks for 3 months. Method of measurement: By standard kit in Imam Hossein hospital.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohammad Bagher Sohrabi

Shahroud University of Medical Sciences

mb.sohrabi@yahoo.com ; mb.sohrabi@shmu.ac.ir+98 27 3334 2000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026