Intracerebral hemorrhage. Nontraumatic intracerebral hemorrhage
Conditions
Interventions
Intervention 1: Intervention group: Nano-curcumin medication with dosage of 80 mg for 12 weeks. Intervention 2: Control group: Patients with cerebral hemorrhage without medication.
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age 18-80 years, Diagnosis of ICH by brain CT scan, NIHSS> 4 and MRS <2 presymptomatic, bleeding in the putamen area, Glasgow criterion (GCS greater than 8) informed consent of the patient or first-degree relatives.
Exclusion criteria
Exclusion criteria: Allergy to turmeric, pregnancy, liver disease with liver enzyme more than three times of normal range kidney disease or creatine more than 2, candidate for surgery and hematoma evacuation, secondary ICH for anticoagulant use and tumor and aneurysm and AVM, infratentorial hemorrhage, platelet count / 75,000 mm3 <, INR <1.4, fever at initial visit, other inflammatory diseases including pneumonia, hematology, rheumatology, urinary tract infection on admission. Immune suppressant drugs,] absorption syndromes, history of diabetes, smoking, alcohol and drug use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of the patient's disability and dysfunction to achieve MRS is below 3. Timepoint: At the time of admission, 24, 48 and 72 hours, 1 week (or last day of hospitalization), 4 weeks and 12 weeks. Method of measurement: MRS questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduce NIHSS to less than the initial 50% and reduce hematoma volume and increase Glasgow score. Timepoint: At the time of admission, 24, 48 and 72 hours, 1 week (or last day of hospitalization), 4 weeks and 12 weeks. Method of measurement: Hematoma size is measured using the formula ABC / 2 (A: The largest diameter in the largest bleeding slice, B the diameter perpendicular to A and C, the approximate number of 10 mm slices in which bleeding occurs). NIHSS Questionnaire and Glasgow scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNarges Karimi
Mazandaran University of Medical Sciences
Outcome results
None listed