Efficacy of topical curcumin on mild to moderate idiopathic carpal tunnel syndrome

Efficacy of topical curcumin on mild to moderate Idiopathic carpal tunnel syndrome: a randomized double-blind placebo controlled clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140221016666N3

Enrollment

Registered

2019-01-19

Start date

2018-09-23

Completion date

Unknown

Last updated

2019-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carpal tunnel syndrome. Carpal tunnel syndrome

Interventions

Intervention 1: Intervention group: Curcumin topical ointment is a turmeric extract and is manufactured by Exir Nanosina.Twice a day in the morning and at the night, 12 hours interval, in the anterio

Eligibility

Sex/Gender

Female

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Female patients aged 18-65 years old completed the informed consent form Sign and symptoms of carpal tunnel syndrome: at least two symptoms or one symptom and one sign including: pain, paresthesia, hypoesthesia, numbness, positive phalen or tinel test Electrodiagnostic evidence suggestive of mild to moderate idiopathic carpal tunnel syndrome

Exclusion criteria

Exclusion criteria: Positive history of the curcumin hypersensitivity Failure to complete the information collection form Cervical radiculopathy or brachial plexopathy, TOS,Protator teres syndrome, ulnar neuropathy Clinical Signs or Electrodiagnostic evidence of Polyneuropathy Rheumatologic disorders such as: rheumatoid arthritis, systemic sclerosis, Lupus, Amyloidosis and so on Endocrine disorders: Diabetes, hypothyroid Conditions that mimic carpal tunnel syndrome, such as multiple sclerosis Pregnancy and lactation Serious cardiovascular disease like heart failure and kidney disease Intravenous injection or physiotherapy for the treatment of carpal tunnel syndrome over the past 6 months A positive history of a severe trauma or fracture of the wrist The inevitable use of corticosteroids or analgesic drugs Patients with severe carpal tunnel syndrome based on clinical or electrodiagnostic evidence

Design outcomes

Primary

Measure	Time frame
Boston questionnaire score and severity of pain according to VAS. Timepoint: Before intervention and Eighth week after treatment. Method of measurement: Boston questionnaire and VAS.;EMG-NCV parameters changes. Timepoint: Before intervention and Eighth week after treatment. Method of measurement: Electrodiagnostic.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNarges Karimi

Sari University of Medical Sciences

Drkarimi_236@yahoo.com+98 11 3311 6275

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026