Diabetes. Insulin-dependent diabetes mellitus
Conditions
Interventions
Intervention 1: Intervention group 1 : In group 1 with general anesthesia (n = 20), pretreatment with midazolam 04/0 mg kg, fentanyl 3 micrograms per kilogram, and the induction of anesthesia with pr
Treatment - Drugs
Intervention group 1 : In group 1 with general anesthesia (n = 20), pretreatment with midazolam 04/0 mg kg, fentanyl 3 micrograms per kilogram, and the induction of anesthesia with propofol 2 mg kg,
Intervention group 2 : For patients in SA group, 3 ml Bupivacaine 0.5% was injected into the subarachnoid space of the spinal canal between the third and fourth lumbar space or between the fifth lumba
Control group: 23 healthy volunteers (age and gender-matched) were recruited to have a control group for a better interpretation of laboratory data in our patients.
Sponsors
Vice Chancellor for Research, Mashhad University of Medical Science
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Diabetic patient with diabetic foot who were candidate for lower limb amputation. Exclusion criteria: Lack of consent to participate in the study; Antioxidant supplements such as vitamin C; Neuraxial uplink block is prohibited; End-stage renal disease.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum total antioxidant capacity. Timepoint: Before induction, 1 hour after surgery. Method of measurement: Antioxidant Assay Kit.;Level of Serum Lipid Peroxidation. Timepoint: Before induction, 1 hour after surgery. Method of measurement: TBARS (Thiobarbitoric Acid Reactive Substances Assay kit). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactArash Peivandi Yazdi
Mashhad University of Medical Sciences
Outcome results
None listed