Effect of Oral Midazolam on Reducing Preoperative Anxiety in Women Aged 20-50 Undergoing Laparotomy: A Randomized Double-Blind Trial

Investigating the effect of oral midazolam in reducing anxiety before surgery in women aged ??-?? years undergoing laparotomy, randomized double blind clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140220016652N2

Enrollment

Registered

2024-11-04

Start date

2024-11-30

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

laparotomy surgery.

Interventions

Intervention 1: Intervention group(A): After selecting the target group, a syringe containing Midazolam in a dose of 7.5-15 mg, plus 4 cc of pomegranate juice (to ensure a pleasant taste), will be pre

Eligibility

Sex/Gender

Female

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: women with ASA grade II or III (American Society of Anesthesiology classification). women between 20 and 50 years old. Candidate for laparotomy surgery. Able to comprehend and communicate in the language.

Exclusion criteria

Exclusion criteria: Allergy to the drugs used in the study History of surgery Positive history of psychological problems Use of benzodiazepines, sedatives and narcotics

Design outcomes

Primary

Measure	Time frame
Blood pressure. Timepoint: Before the intervention and one hour after. Method of measurement: Monitoring.;Electrocardiogram. Timepoint: Before the intervention and one hour after. Method of measurement: ECG examination.;Heart rate. Timepoint: Before the intervention and one hour after. Method of measurement: Monitoring.;Catecholamine. Timepoint: Before the intervention and one hour after. Method of measurement: Blood test.;Anxiety. Timepoint: Before the intervention and one hour after. Method of measurement: Spielberger anxiety test.	—

Measure

Time frame

Blood pressure. Timepoint: Before the intervention and one hour after. Method of measurement: Monitoring.;Electrocardiogram. Timepoint: Before the intervention and one hour after. Method of measurement: ECG examination.;Heart rate. Timepoint: Before the intervention and one hour after. Method of measurement: Monitoring.;Catecholamine. Timepoint: Before the intervention and one hour after. Method of measurement: Blood test.;Anxiety. Timepoint: Before the intervention and one hour after. Method of measurement: Spielberger anxiety test.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNasim Ahmadi Doost

Shiraz University of Medical Sciences

nassimahmadidoost@gmail.com+98 71 3647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026