hepatotoxicity. Hepatic failure (acute)(chronic) due to drugs
Conditions
Interventions
Intervention 1: Experimental 3(aerobic exercise, nanoparticles & anesthesia): in this group, at first rats ran on a treadmill then anesthetized and iron oxide nanoparticles were injected into their tr
Treatment - Drugs
Diagnosis
Experimental 3(aerobic exercise, nanoparticles & anesthesia): in this group, at first rats ran on a treadmill then anesthetized and iron oxide nanoparticles were injected into their trachea. Aerobic e
Experimental group (1)(aerobic exercise): in this group male wistar rats were trained to do low-intensity aerobic exercise. With an intensity of approximately 35% to 40% VO2max, they ran on a motor-dr
Experimental 2(nanoparticle, anesthesia): as concerns intratracheal instillation for every injection, a 0.1ml dose of 100mg/ml distilled water and IONPs suspension solution has been injected into the
Control group: this group did not receive any intervention and were weighed every day.
Placebo 4(distillated water, anesthesia): as concerns intratracheal instillation for every injection, a 0.1ml distilled water has been injected into the rat's thetrachea. Administration repeated 7 ti
Placebo 5(aerobic exercise, anesthetists): at first rats ran on a treadmill then anesthetized and weighed. Rats were trained to do low-intensity aerobic exercise. With an intensity of approximately 35
Sponsors
vice chancellor for research, Islamic Azad University Isfahan(Khorasgan)Branch
Eligibility
Sex/Gender
Male
Age
1 Years to 1 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: public health; physical ability; normal limbs Exclusion criteria: physical disability.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ALT. Timepoint: 14 days after the intervention. Method of measurement: Enzyme units per liter.;AST. Timepoint: 14 days after the intervention. Method of measurement: Enzyme units per liter.;ALP. Timepoint: 14 days after the intervention. Method of measurement: Enzyme units per liter. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hepatic tissue sections. Timepoint: 14 days after the intervention. Method of measurement: Observed slides hepatic tissues sections. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDoctor Gholamreza Sharifi
Islamic Azad University Isfahan(Khorasgan) Branch
Outcome results
None listed