Condition 1: Pain in throat. Condition 2: Nausea and vomiting. Pain in throat Nausea and vomiting
Conditions
Interventions
Intervention 1: Intravenous ketamine 0.25 mg/kg (2 ml) single dose plus intravenous acetaminophen 15 mg/kg single dose, 15 min before the end of surgery and every 6 hours until 24 hours after surgery.
Treatment - Drugs
Placebo
Intravenous ketamine 0.25 mg/kg (2 ml) single dose plus intravenous acetaminophen 15 mg/kg single dose, 15 min before the end of surgery and every 6 hours until 24 hours after surgery.
Intravenous normal saline 2 ml single dose plus intravenous acetaminophen 15 mg/kg single dose, 15 min before the end of surgery and every 6 hours until 24 hours after surgery.
Sponsors
Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
3 Years to 12 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (a) 3 to 12 years old; (b) candidate for elective adenotonsilectomy; having one or two criteria based on Physical Status Classification American Society of Anesthesiologists (ASA) Exclusion criteria: (a) history of psychiatric disease; (b) using analgesic within 24 hours before surgery; (c) sensitivity to ketamine or acetaminophen; (d) using cautery for hemostasis.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain severity. Timepoint: at 0.5, 6, 12, and 12 hours after surgery. Method of measurement: based on the CHEOPS Pain Score.;Number of nausea and vomiting. Timepoint: at 0.5, 6, 12, and 12 hours after surgery. Method of measurement: based on clinical observation. | — |
Secondary
| Measure | Time frame |
|---|---|
| The duration of time to use the first narcotic. Timepoint: per min after surgery. Method of measurement: based on medical record. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Lida Noori
Beasat Hospital
Outcome results
None listed